摘要
在环境因素中,如饮食、地域、抗生素治疗、补充益生菌、肠内营养等对肠道菌群产生的影响与炎症性肠病的发生、发展密切相关。对于肠道菌群的作用机制的学说包罗万千,可以说是对宿主的各个方面都产生了影响。尽管益生菌的作用机制没有被破译,但是它们可以刺激黏液分泌,抑制致病菌定植,纠正菌群失衡,改善屏障功能,下调先天免疫系统受体的表达,平衡T细胞亚群之间的均衡,改变一些基因的表达。另外免疫调节还产生了短链脂肪酸和其他代谢产物,这些对炎症性肠病的发病都是非常重要的。
The influence of environmental factors such as diet, region, antibiotic treatment, supplemental probiotics and enteral nutrition on intestinal flora is also closely related to the occurrence and development of IBD. The theory of the mechanism of intestinal flora contains thousands of factors, which have impacts on every aspect of the host. Although the mechanisms of probiotics have not been explained clearly, they can stimulate mucus secretion, inhibit bacterial colonization, correct bacterial imbalances, improve barrier function, downregulate the expression of innate immune system receptors, balance the subsets of T cells, and change the expression of some genes. In addition, immunoregulation also produces short chain fatty acid and other metaholites, which are very important for the pathogensis of IBD.
作者
田雨
李俊霞
王化虹
Tian Yu;Li Junxia;Wang Huahong(Department of Gastroenterology,Peking University First Hospital,Beijing 100034,China)
出处
《临床荟萃》
CAS
2018年第8期661-665,共5页
Clinical Focus
关键词
炎症性肠病
肠内营养
肠道菌群
inflammatory bowel disease
enteral nutrition
enterobacteriaceae
