摘要
目的分析急诊重症监护室(emergency intensive care unit,EICU)患者急性生理和慢性健康状况评分(APACHEⅡ评分)及促炎因子与临床结局之间的关系。方法随机收集2016—2017年EICU收治的103例住院患者,根据APACHEⅡ评分分为高危组和低危组。分别检测记录并比较两组患者TNF-α、IL-6、IL-8及死亡率,并分析APACHEⅡ评分与其他各指标之间的相关性。结果高危组患者的TNF-α、IL-6、IL-8均显著高于低危组(P<0.05),且高危组死亡率与低危组比较,差异有统计学意义(P<0.05);APACHEⅡ评分与IL-6、IL-8、TNF-α、死亡率成正相关(P<0.05)。结论 APACHEⅡ评分结合IL-6、IL-8、TNF-α能够有效地判断EICU患者的疾病危重程度及预测患者的临床结局。
Objective To examine the relationship of clinical outcomes with acute physiology andchronic health status （ APACHE Ⅱ scores） and serum proinflammatory factor levels in acuteintensive care unit （ EICU） patients. Methods One hundred and three patients admitted in EICUfrom 2016 to 2017 were enrolled in the study. According to APACHE Ⅱ scores, patients wereclassified as high risk group （n = 45） and low risk group （n = 58）. The serum levels of TNF.α, IL.6,IL.8 were measured, the incidence of death was documented in two groups. The correlation of clinicaloutcomes with APACHE Ⅱ scores, serum proinflammatory factor levels and other indicators wasanalyzed. Results The serum levels of TNF.α, IL.6 and IL.8 in the high.risk group were significantlyhigher than those in the low.risk group （P〈0. 05）, and the incidence of death in the high.risk groupwas significantly higher than that in the low.risk group （P〈0. 05）. APACHE Ⅱ scores was positivelycorrelated with IL.6, IL.8, TNF.α and the case fatality rate （P〈0. 05）. Conclusion APACHE Ⅱscores combined with IL.6, IL.8, TNF.α can determine the severity of EICU patients and predict theclinical outcomes of patients.
作者
罗斌
戴国兴
陈莹
李莹杰
吴萍
LUO Bin;DAI Guo-xing;CHEN Ying;LI Ying-jie;WU Ping(Dept.of Clinical Nutrition,Tongji Hospital,Tongji University,Shanghai 200065,China;Dept.of Emergency,Tongji Hospital,Tongji University,Shanghai 200065,China;Dept.of Gastroenterology,Tongji Hospital,Tongji University,Shanghai 200065,China)
出处
《同济大学学报（医学版）》
CAS
2018年第4期78-81,共4页
Journal of Tongji University(Medical Science)
基金
国家自然科学基金青年项目(81502041)
