摘要
三结构域蛋白（TRIM）家族是一个重要的蛋白家族，其在细胞生物学过程中具有多种功能，包括细胞内信号传导、细胞生长及凋亡、固有免疫、自噬和肿瘤发生等。许多研究证实TRIM在肝细胞癌中呈特异性表达，与肝细胞癌的发生、转移及预后密切相关。TRIM有望成为监测肝细胞癌发生发展的标志物，在早期诊断、治疗和预后判断等方面具有广阔前景。
Tripartite motif （TRIM） family, a very important protein family, has various functions in cellular biological processes including intracellular signal transduction, cell growth and apoptosis, innate immunity, autophagy and tumorigenesis. The specific expressions of TRIM in hepatocellular carcinoma are proved by many researches, which are closely related to the occurrence, metastasis and prognosis of hepatocellular carcinoma. TRIM are expected to be markers for the occurrence and development of hepatocellular carcinoma, and have broad prospects in the early diagnosis, therapy and prognosis of hepatocellular carcinoma.
作者
李蒙
贺德
Li Meng;He De(Postgraduate College of Guangdong Medical University,Zhanjiang 524023,Chin;Department of General Surgery,Affiliated Bao＇an Hospital of Southern Medical University,Shenzhen 518101,Chin)
出处
《国际肿瘤学杂志》
CAS
2018年第6期375-378,共4页
Journal of International Oncology
关键词
癌
肝细胞
三结构域家族
Carcinoma, hepatocellular
Tripartite motif family
