摘要
目的探讨不同BMI的T2DM患者血浆血管内皮生长因子B(VEGF-B)水平的变化。方法 167例T2DM患者根据BMI分为正常体重组(Con)55例、超重组(Ow)57例及肥胖组(Ob)55例。采用ELISA测定各组VEGF-B水平,分析其与BMI、血糖、血脂、胰岛素抵抗指数(HOMA-IR)等指标的关系。结果 VEGF-B水平在Con、Ow、Ob组分别为(80.56±23.15)、(110.19±46.87)、(158.21±55.46)pg/ml,组间两两比较,差异有统计学意义(P<0.05)。相关分析显示,VEGF-B水平与BMI、WHR、FPG、HbA1c、TG、FIns、HOMA-IR、HDL-C相关(r=0.414、0.341、0.274、0.285、0.264、0.358、0.452、-0.325,P<0.05或P<0.01);多元逐步回归分析显示,BMI、HOMA-IR是VEGF-B水平独立影响因素(t=2.594、1.650,P<0.01)。结论 T2DM患者VEGF-B水平与BMI关系密切,随着BMI的增加,VEGF-B水平逐渐升高。
Objective To investigate the plasma vascular endothelial growth factor-B（VEGF-B）levels and its clinical value in type 2 diabetic patients with different body mass index（BMI）. MethodsA total of 167 patients with type 2 diabetes（T2 DM）were enrolled in this study and divided into three groups according to BMI：normal weight group（Con,n=55）,over-weight group（Ow,n=57）and obese group（Ob,n=55）.Plasma VEGF-B level was measured by ELISA.The relationship between plasma VEGF-B levels and BMI,blood glucose,blood lipid,HOMA-IR was analyzed. Results The levels of VEGF-B were（80.56±23.15）,（110.19±46.87）and（158.21±55.46）pg/ml in Con,Ow and Ob groups respectively.The differences of pairwise comparison among the three groups were statistically significant（P〈0.05）.Correlation analysis showed that VEGF-B level was correlated with BMI,WHR,FPG,HbA1c,TG,FIns,HOMA-IR and HDL-C（r=0.414,0.341,0.274,0.285,0.264,0.358,0.452,-0.325,P〈0.05 or P〈0.01）.Logistic regression analysis showed that BMI and HOMA-IR were independent influencing factors for VEGF-B（t=2.594,1.650,P〈0.01）. Conclusion VEGF-B is closely related to BMI.The level of VEGF-B increased together with the increase of BMI in patients with T2 DM.
作者
杨华
杨晓东
饶丽华
刘云涛
潘静芳
YANG Hua , YANG Xiaodong , RAO Lihua , et al.(Department of Clinical Laboratory ,Renhe Hospital of Three Gorges UniverSity ,Yichang 443001 ,China)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2018年第8期644-646,共3页
Chinese Journal of Diabetes
关键词
血管内皮生长因子B
糖尿病
2型
体重指数
Vascular endothelial growth factor-B
Diabetes mellitus
type 2
Body mass index
