摘要
环状RNA是以共价闭合环为特征的非编码RNA,可通过转录调控机制影响细胞转导、蛋白质合成等生物学功能,与多种疾病的发病机制有关,是一类崭新的生物标志物。该文就环状RNA的来源、结构、功能、研究方法进行介绍,并初步探究了环状RNA在结核病研究中的应用。
Circular RNA are one kind of non-coding RNA, charactered by covalently closed rings. They can influence biological functions such as cell transduction and protein synthesis. They are associated with pathogenesis of many diseases and become a novel family of biomarkers. Now we try to introduce the origin, structure, function of circular RNA and the involved research methodology. Furthermore, we primarily discuss their application in the tuberculosis research.
作者
王旻晋
陈雪融
WANG Minjin;CHEN Xuerong(Department of Laboratory Medicine,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,P.R.China;Department of Respiratory and Critical Care Medicine,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,P.R.China)
出处
《华西医学》
CAS
2018年第8期1023-1027,共5页
West China Medical Journal
基金
国家科技重大专项艾滋病和病毒性肝炎等重大传染病防治项目(2012ZX10004-901)
