摘要
目的探讨EB病毒(Epstein-barr virus)感染在儿童腺样体肥大发病机制中的作用。方法采用荧光定量PCR技术对51例急、慢性腺样体肥大患儿的血浆标本进行EB病毒DNA定量检测,同时将其根据性别、体重、腺样体肥大症状轻重、是否伴有反复呼吸道感染等因素分为不同组别,比较不同组别之间的EB病毒感染情况。结果在51例患有腺样体肥大的患儿中,有31例伴有EB病毒感染。其中男性儿童为60.7%(17/28),女性儿童为60.9%(14/23)。2组之间差异无统计学意义;体重为0~15 kg的患儿感染率为57.1%(8/14),15~25 kg为62.9%(17/27),25~40 kg为60%(6/10),不同体重感染率无明显差异性。比较轻、中、重度腺样体肥大儿童的EB病毒DNA拷贝数发现:重度肥大的儿童EB病毒DNA拷贝数明显高于其他2组,3组之间有明显差异性。急性期腺样体肥大多为传单病的一个表现,同时伴有反复呼吸道感染的患儿EB病毒感染率为92.86%(26/28),不伴有反复呼吸道感染的患儿其EB病毒感染率为21.7%(5/23),2组之间有明显差异性。结论儿童腺样体肥大与EB病毒的感染之间存在一定的关联性,尤其是对于患有反复呼吸道感染的儿童,EB病毒的感染是其主要致病因素。腺样体肥大患儿EB病毒感染率与患者的体重、性别等因素无明显相关性。
Objective To study the correlation of Epstein-Barr virus（EB） infection and adenoid hypertrophy in children. Methods Fifty-one children with adenoid hypertrophy from the January 2015 to December in our hospital were included in this research. According to the Children＇s sex, weight, the degree of adenoidal hypertrophy, recurrent respiratory tract infection etc, they were divided into different groups. And EB infection was evaluated and compared. Results In 51 cases of children with adenoid hypertrophy, 31 cases infected with EB virus. Among the EB-DNA positive cases, the male children accounted for 60.7%（17/28）, while female patients accounted for 60.9%（14/23）. EB infection rates among the two groups had no significant difference（P〉0.005）. EB infection rate in children of body weight of 0～15 kg was 57.1%（8/14）, 62.9%（17/27） of 15～25 kg, 60%（6/10）of 25～40 kg. Children with different weight had no significant difference in EB infection（P〉0.05）. About the degree of adenoidal hypertrophy in accordance with mild, moderate,severe contrast, the number of children with EB virus DNA severe group was significantly higher than the other two groups, there are significant differences between the three groups（P〈0.05）, and about fact of recurrent respiratory tract infection. The rate of EB virus infection in children with recurrent respiratory tract infection was 92.86%（26/28）, the rate of EB virus infection in children without recurrent respiratory tract infection was 21.7%（5/23）, and there was significant difference between the two groups（P〈0.05）.Conclusion There is a certain relationship between adenoid hypertrophy in children with EB virus infection, especially for children with recurrent respiratory tract infection, EB virus infection is the main pathogenic factors of adenoid hypertrophy in children. EB virus infection rate was no significant correlation between gender and weight or other factors of the patient.
作者
杨一海
刘丕松
刘英
YANG Yi-hai1, 2, LIU Pi-song1, 2, LIU Ying1, 2(1. Department of Pediatrics, the First People＇s Hospital, Datong Shanxi, 037009;2. Affiliated Hospital of Shanxi Datong University, Datong Shanxi, 03700)
出处
《山西大同大学学报（自然科学版）》
2018年第4期58-59,65,共3页
Journal of Shanxi Datong University(Natural Science Edition)
基金
山西省软科学基金资助项目[2013041069-03]
山西省科技攻关资助项目[20130313020-1]
关键词
儿童
腺样体肥大
EB病毒
children
adenoidal hypertrophy
Epstein-Barr virus
