摘要
目的:探讨布地奈德雾化吸入治疗妊娠并发支气管哮喘急性发作患者临床价值。方法:选自本院于2016年3月—2018年3月期间门诊就诊的妊娠并发支气管哮喘急性发作患者94例,依据随机数字表法分为观察组47例与对照组47例。对照组患者入院后给予吸氧、纠正电解质失衡、消炎、补液、抗感染等常规治疗,且给予特布他林雾化液吸入,2.5 mg/次,15~30 min/次,2次/d;观察组在上述治疗基础上雾化吸入布地奈德混悬液,2 mg/次,2次/d,15~30 min/次。两组疗程均为7 d。比较两组疗效,治疗前后主要症状积分、肺功能变化及不良反应发生情况。结果:观察组总有效率(93.62%)高于对照组(72.34%)(P<0.05)。两组治疗后咳嗽、胸闷和喘息积分降低(P<0.05);观察组治疗后咳嗽、胸闷和喘息积分低于对照组(P<0.05)。两组治疗后PEF增加(P<0.05);观察组治疗后PEF高于对照组(P<0.05)。两组无明显不良反应。结论:妊娠并发支气管哮喘急性发作患者布地奈德雾化吸入治疗效果显著,具有重要临床研究意义,值得推广应用。
Objective： To explore the clinical value of budesonide inhalation in the treatment of acute exacerbation of bronchial asthma in pregnant women. Methods： Nighty-four cases of acute attack of asthma complicated with pregnancy from March 2016 to March 2018 were selected and randomly divided into 47 cases in the observation group and 47 cases in the control group. Control group was treated with routine therapies like oxygen inhalation,correction of electrolyte imbalance,antiphlogosis,fluid infusion and anti-infection treatment after admission,combing with aerosol inhalation of Terbutaline Solution for Nebulization at a dose of2. 5 mg per time,15 to 30 min per time,bid. On this basis,observation group was added with aerosol inhalation of Budesonide Suspension 2 mg per time,15 to 30 min per time,bid. The treatment course for both groups lasted for seven days. The therapeutic effects,the scores of main symptoms,pulmonary function and adverse reactions before and after treatment were compared between the two groups. Results： The total effective rate of the observation group（ 93. 62%） was higher than that of the control group（ 72. 34%）（ P〈0. 05）. The scores for cough,chest tightness and wheezing in the two groups were reduced. Scores for cough,chest tightness and wheezing in the observation group were lower than those in the control group. PEF in the observation group were higher than those of the control group（ P〈0. 05）. No obvious adverse reaction was found in both the groups. Conclusion： Budesonide Inhalation in the treatment of acute attack of asthma complicated with pregnancy is significant,and has important clinical value. It is worth popularizing.
作者
周莉
王平
Zhou Li;Wang Ping(Nantong Maternal and Child Health Care Hospital,Nantong 22600)
出处
《天津药学》
2018年第4期42-44,共3页
Tianjin Pharmacy
