摘要
目的探讨他氟前列素滴眼液对初始用药、单药或多种药物降压控制不佳的开角型青光眼患者的降眼压疗效。方法将66例116眼诊断为原发性开角型青光眼患者纳入本研究,分为首选治疗组18例36眼、联合用药组26例38眼和替换治疗组22例42眼。每晚使用他氟前列素滴眼液1次,每次一滴。在治疗前以及治疗后4周和12周进行Goldmann压平眼压计测量眼压,测量时间均为早上8-9点;进行视力、裂隙灯下眼前段检查、角膜荧光素染色及眼底镜检查;在用药前与治疗后12周行Humphery视野检查,记录各组结果并进行相关统计学分析。结果首选治疗组治疗前眼压为(24.6±3.6)mm Hg(1 k Pa=7.5 mm Hg);治疗后4周和12周眼压分别为(18.8±1.5)mm Hg、(18.6±1.7)mm Hg,分别下降(5.7±2.1)mm Hg、(6.1±2.3)mm Hg,与治疗前比较,差异均有统计学意义(t=14.365、17.238;均为P<0.001)。联合用药组治疗前眼压为(25.7±5.7)mm Hg;治疗后4周和12周眼压分别为(18.7±3.4)mm Hg和(17.4±3.2)mm Hg,分别下降(6.6±3.5)mm Hg、(6.8±3.7)mm Hg,与治疗前比较,差异均有统计学意义(t=12.840、13.365;均为P<0.001)。替换治疗组治疗前眼压为(22.8±5.6)mm Hg;治疗后4周和12周眼压分别为(17.1±3.2)mm Hg、(16.2±2.6)mm Hg,分别下降(5.6±3.8)mm Hg、(6.6±4.2)mm Hg;其中替换β受体阻滞剂与前裂腺素类药物降压治疗,治疗后4周与12周眼压下降幅度在替换β阻滞剂组(5.0±4.1)mm Hg、(6.3±4.1)mm Hg,在替换PG类药物组为(5.8±2.5)mm Hg、(6.4±4.7)mm Hg,治疗后12周同治疗前比较,差异均有统计学意义(t=12.095、13.070;均为P<0.001)。共有7眼患者出现不良反应,为轻到中度结膜充血,未见角膜染色。治疗前视野缺损为(5.4±1.8)d B,治疗后12周为(5.6±1.4)d B,治疗前后差异无统计学意义(P>0.05)。结论他氟前列素滴眼液能有效降低原发性开角型青光眼患者的眼压;对首选用药、替代治疗及联合用药,他氟前列素滴眼液均能有效�
Objective To evaluate the efficacy of Tafluprost for intraocular pressure （IOP） in patients with primary open angle glaucoma.Methods This study included 66 adult patients with 116 eyes who were diagnosed as primary open-angle glaucoma（POAG）.These patients were grouped into first choice group with 36 eyes in 18 patients,the combination group with 38 eyes in 26 patients and the alternative treatmetn group with 42 eyes in 22 patients.All the patients were treated with Tafluprost 0.0015% once every night.The IOP measurements by Goldmannapplanation tonometer,the visual acuity,slit lamp microscope examination,corneal fluorescein test and fundus examination were conducted before treatment,4 weeks and 12 weeks after treatment.IOP measurements were performed at 8-9 AM at the follow-up visits.The vision field was tested before treatment and 12 weeks after the medication.All results documented and statistical analyzed.Results For patients in first choice group of Tafluprost,the mean IOP was （24.6±3.6）mmHg （1 kPa=7.5 mmHg） before treatment,and after treatment for 4 weeks and 12 weeks,the mean IOP was （18.8±1.5）mmHg and （18.6±1.7）mmHg,respectively,and the decrease of IOP was （5.7±2.1）mmHg and （6.1±2.3）mmHg,respectively.By compared with before treatment,the difference was statistically significant （ t =14.365,17.238; P 〈0.001）.The IOP was significantly decreased.In the combination group,the average IOP was （25.7±5.7）mmHg before treatment,and after 4 weeks and 12 weeks of treatment,the average IOP was （18.7±3.4）mmHg and （17.4±3.2）mmHg,respectively,and the average decrease of IOP was （6.6±3.5）mmHg,（6.8±3.7）mmHg after treatment,respectively.Compared with before treatment,the difference was statistically significant （ t =12.84,13.365;all P 〈0.001）.In the alternative treatment group,the average IOP was （22.8±5.6）mmHg,（17.1±3.2）mmHg and （ 16.2± 2.6）mmHg for before treatment,4 weeks and 12 weeks after treatment,respectively,and the average decrea
作者
董志章
甘一峰
张易南
郑海华
DONG Zhi-Zhang;GAN Yi-Feng;ZHANG Yi-Nan;ZHENG Hai-Hua
出处
《眼科新进展》
CAS
北大核心
2018年第9期856-860,共5页
Recent Advances in Ophthalmology
基金
浙江省自然科学基金资助(编号：LY18H120009)
关键词
开角青光眼
他氟前列素
眼压
open angle glaucoma
tafluprost
intraocular pressure
