摘要
缺血性脑卒中缺乏有效的治疗措施,目前应用于临床的许多药物受到血脑屏障的限制,难以充分发挥疗效。EGb761是银杏制剂的提取物,在改善心脑血管疾病方面积累了大量证据。为提高其局部血药浓度,我们采用侧脑室微量泵泵入EGb 761,并观察其对大脑中动脉缺血-再灌注(MCAO)大鼠脑区细胞凋亡的影响,探讨其作用机制及侧脑室注射途径的可行性。
There is no effective treatment for ischemic stroke, and many drugs currently used in the clinic are limited by the blood-brain barrier and it is difficult to fully exert its effect. EGb 761 is an extract of Ginkgo biloba, which has accumulated a lot of evidence in improving cardiovascular and cerebrovascular diseases. In order to increase its local plasma concentration, we used a lateral pump to pump EGb 761, and observed its effect on the apoptosis of brain regions in MCAO rats, and explored its mechanism of action and lateral injection pathway feasibility.
作者
孙灵芝
孟苗苗
刘芹
曹晓岚
SUN Lingzhi;MENG Miaomiao;LIU Qin;CAO Xiaolan(Department of Encephalopathy,the Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan 250011,China;College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan 250014,China;The First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan 250014,China)
出处
《中国中医药现代远程教育》
2018年第14期93-96,共4页
Chinese Medicine Modern Distance Education of China
基金
国家中医药管理局全国名老中医药专家曹晓岚传承工作室项目
