摘要
目的总结多奈呱齐和丁苯酞联合使用进行老年脑梗死后血管性痴呆治疗效果。方法选择该院从2016年11月—2017年10月期间收治的老年脑梗死以后的血管性痴呆患者92例作为研究对象,按随机原则分成对照组46例和观察组46例,对照组患者均给予阿司匹林等药物来防止梗死的复发,并且给予丁苯酞软胶囊进行口服。观察组患者在对照组治疗的基础上,另外联合使用药物盐酸多奈呱齐片,该两组都治疗12周以后,计算和统计两组患者在治疗前后的临床痴呆评定量表(CDR)评分值、认知功能评分值(MMSE)和日常生活能力评分值(ADL),并对治疗效果进行评价对比。结果经过12周治疗,观察组患者的总有效率为93.5%(43/46),显著的高于对照组(80.4%,37/46),两组患者的总有效率对比,差异有统计学意义(χ2=5.317,P<0.05);在治疗后,观察组患者CDR、MMSE和ADL评分值分别为(4.5±0.5)分、(26.1±3.5)分和(76.0±4.7)分,各项评分显著优于对照组,两组上述指标对比,差异有统计学意义(P<0.05)。结论药物多奈呱齐联合丁苯酞对于老年脑梗死以后血管痴呆患者,可以明显改善患者的认知功能和生活自理能力,从而缓解患者的痴呆症状,且安全性良好,值得临床推广。
Objective To summarize the therapeutic effect of dopaminide and butylphthalide in the treatment of vascular dementia after cerebral infarction in the elderly. Methods 92 patients with vascular dementia after cerebral infarction in the hospital from November 2016 to October 2017 were selected as study subjects. According to the randomized principle, 46 patients were divided into control group and 46 patients in observation group. Aspirin and other drugs are given to prevent the recurrence of infarct, and oral administration of butylphthalide soft capsules. The patients in the observation group were additionally treated with the drug Donepzine Hydrochloride Tablets on the basis of the treatment in the control group. After 12 weeks of treatment in both groups, the clinical dementia rating scale（CDR） scores before and after treatment were calculated and calculated for the two groups of patients. Values, cognitive function scores（MMSE）, and ADL were compared and evaluated for efficacy. Results After 12 weeks of treatment, the total effective rate in the observation group was 93.5%（43/46）, which was significantly higher than that in the control group（80.4%,37/46）. The difference was statistically significant（χ^2=5.317, P〈0.05）; After treatment, the CDR, MMSE, and ADL scores in the observation group were（4.5 ±0.5）points,（26.1±3.5）points, and（76.0 ±4.7）points, respectively. Significantly better than the control group, the comparison of the above two indicators, the difference was statistically significant（P〈0.05）.Conclusion The drug dopeicidine combined with butylphthalide can significantly improve the cognitive function and self-care ability of patients with vascular dementia after senile cerebral infarction, so as to relieve the symptoms of dementia in patients with good safety and worthy of clinical promotion.
作者
余莉
YU Li(Department of Neurology, Changehun Central Hospital, Changehun, Jilin Province 130000 China)
出处
《系统医学》
2018年第12期66-68,共3页
Systems Medicine
关键词
血管性痴呆
认知功能障碍
脑梗死
丁苯酞
多奈呱齐
Vascular dementia
Cognitive dysfunction
Cerebral infarction
Butylphthalide
Donetazig
