摘要
目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者单核细胞/高密度脂蛋白比值及其临床意义。方法选取OSAHS患者86例作为OSAHS组,根据呼吸暂停低通气指数(AHI)分为轻度组32例、中度组30例和重度组24例,另选取经多导睡眠监测检查排除OSAHS的健康受试者32例作为对照组。比较各组的单核细胞计数(MC)、HDL-C和MHR,并分析OSAHS患者的血清MC、HDL-C和MHR与AHI和最低血氧饱和度的相关性。结果 OSAHS组患者MC、MHR高于对照组,而HDL-C低于对照组(P<0.05)。OSAHS重度组、中度组、轻度组MC和MHR依次降低(均P<0.05)。相关分析显示,OSAHS患者MC、MHR分别与AHI呈正相关,与最低血氧饱和度呈负相关,HDL-C与最低血氧饱和度呈正相关(均P<0.05)。结论 OSAHS患者的MHR升高,且MHR随OSAHS严重程度的增加而升高,提示MHR可能是预测OSAHS及其严重程度的新型炎症因子。
Objective To investigate the monocyte count-to-high density lipoprotein-cholesterol ratio（ MHR） in obstructive sleep apnea hypopnea syndrome（ OSAHS） and its clinical significance. Methods Totally 86 patients with OSAHS were enrolled as OSAHS group,and were divided into mild group（ n = 32）,moderate group（ n = 30） and severe group（ n = 24） according to the apnea-hypopnea index（ AHI）. Another 32 healthy subjects without OSAHS confirmed by polysomnography were selected as control group. The monocyte count（ MC）,HDL-C and MHR were compared among all groups. And the correlations of serum MC,HDL-C and MHR with AHI and the lowest blood oxygen saturation were analyzed. Results MC and MHR were higher but HDL-C level was lower in the OSAHS group than those in the control group（ P〈0. 05）. MC and MHR decreased in turn in the severe,moderate and mild OSAHS groups（ all P〉0. 05）.Pearson correlation analysis revealed that MC or MHR positively correlated with AHI,but negatively correlated with the lowest blood oxygen saturation,and HDL-C positively correlated with the lowest blood oxygen saturation（ all P〈0. 05）. Conclusion Elevated MHR is seen in the OSAHS patients and MHR increases with the increasing severity of OSAHS,indicating MHR might be a new inflammatory factor for predicting the severity of OSAHS.
作者
童梓德
赖世佳
TONG Zhi-de ,LAI Shi-jia(Department of Otolaryngology, Affiliated Cheng Gong Hospital of Xiamen University, Xiamen 361003, China)
出处
《广西医学》
CAS
2018年第12期1321-1323,共3页
Guangxi Medical Journal
