摘要
目的观察血必净联合无创正压通气治疗慢性阻塞性肺疾病急性加重期(AECOPD)合并呼吸衰竭患者的临床效果。方法选取2016年3月~2017年10月南阳市宛城区第一人民医院收治的76例AECOPD合并呼吸衰竭患者,采用随机数表法分组,各38例。两组均予以常规治疗,对照组予以无创正压通气治疗,观察组在对照组基础上予以血必净治疗。对比两组临床疗效、血液流变学指标[纤维蛋白原(FBG)、红细胞比容(Hct)、D-二聚体(D-D)]及动脉血气指标[动脉血氧分压(PaO2)、二氧化碳分压(PaCO2)]水平。结果两组治疗总有效率对比,观察组81.58%高于对照组60.53%,差异有统计学意义(P<0.05);治疗后两组Pa O2水平较治疗前高,PaCO2水平较治疗前低,且观察组PaCO2水平较对照组低,差异有统计学意义(P<0.05);治疗后两组血清FBG、Hct、D-D水平对比,观察组较对照组低,差异有统计学意义(P<0.05)。结论血必净联合无创正压通气治疗AECOPD合并呼吸衰竭患者,可提高治疗效果,改善血液流变学及动脉血气情况。
Objective To investigate the clinical effect of Xuebijing combined with noninvasive positive pressure ventilation in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD） and respiratory failure. Methods From March 2016 to October 2017, 76 cases of AECOPD patients with respiratory failure in our hospital were selected and grouped by a random number table method with 38 cases in each group. The two groups were treated with routine treatment, and the control group was treated with noninvasive positive pressure ventilation, and the observation group was treated with Xuebijing on the basis of the control group. The clinical efficacy, and the levels of blood rheology index [fibrinogen（FBG）, hematocrit（Hct）, D-dimer（D-D）] and arterial blood gas index [arterial partial pressure of oxygen（PaO2） and partial pressure of carbon dioxide（PaCO2）] of the two groups were compared. Results The total effective rate of treatment in the two groups was compared, and the 81.58% in the observation group was higher than 60.53% in the control group, and the difference was statistically significant（P 〈 0.05）. After treatment, the level of PaO2 in the two groups was higher than that before the treatment, and the level of PaCO2 was lower than that before the treatment, and the level of PaCO2 in the observation group was lower than that in the control group. The difference was statistically significant（P 〈 0.05）. After the treatment, the levels of serum FBG, Hct and D-D were compared in the two groups. The observation group was lower than the control group, and the difference was statistically significant（P 〈 0.05）. Conclusion Xuebijing combined with noninvasive positive pressure ventilation in the treatment of AECOPD patients with respiratory failure can improve the therapeutic effect and improve the blood rheology and arterial blood gas.
作者
李红哲
吕藏
LI Hong-zhe;LV Zang(Internal medicine,The first people＇s Hospital of Wancheng District,Nanyang,Hennan,473000,China;Intensive medicine department,People＇s Hospital of Zhengzhou,Henan,450000,China)
出处
《临床研究》
2018年第6期78-80,共3页
Clinical Research
关键词
慢性阻塞性肺疾病急性加重期
呼吸衰竭
血必净
无创正压通气
acute exacerbation of chronic obstructive pulmonary disease
respiratory failure
xuebijing
noninvasive positive pressure ventilation
