摘要
目的观察1%硝酸硫康唑喷雾剂治疗足癣的有效性及安全性,局部鞋袜应用1%硝酸硫康唑喷雾剂干预对预防足癣复发的作用。方法将120例诊断为足癣的患者随机分为两组,分别给予1%硝酸硫康唑喷雾剂及2%硝酸咪康唑乳膏治疗,分别于治疗2周、4周后计算其有效率及评价安全性。治愈后的30例患者给予鞋袜抗真菌干预即继续应用1%硝酸硫康唑喷雾剂喷鞋袜1个月,与治疗后未干预的30例患者随访比较其复发情况。结果 1%硝酸硫康唑喷雾剂和2%硝酸咪康唑乳膏对足癣患者的4周后有效率分别为92.1%%和81.1%,两组间比较无统计学差异(P=0.085);治愈后鞋袜干预及未干预组1个月后复发率分别为10%和26.7%,二者间比较有统计学差异(P=0.038)。结论 1%硝酸硫康唑喷雾剂对足癣患者安全有效,鞋袜用药抗真菌干预有助于降低足癣复发率。
Objective To evaluate the efficacy and safety of sulconazole nitrate spray 1%in the treatment of tinea pedis and to observe the effect of spraying the socks and shoes on preventing the disease from recurrence.Methods One hundren and twenty patients diagnosed as tinea pedis were randomly divided into two groups,being treated with sulconazole nitrate spray1%and miconazole nitrate cream 2%respectively.The clinical efficacy was evaluated after two weeks and four weeks.30 clinically cured patients would continue to spray their shoes and socks to control the local environmental fungi for one month.Then the recurrence rate was compared with that of the other 30 patients without any further treatment.Results Clinical efficiency of experimental and control groups were 90.48% and 49.23% respectively after 4 weeks.There was no significant difference between the two groups（P=0.085）.The recurrence rates of the group who had continued to spray the socks and shoes and the group who had not continued to use drugs were respectively 10% and 26.7%.The difference was statistically significant（P=0.038）.Conclusion This study suggested that sulconazole nitrate spray 1% was effective and safe in the treatment of tinea pedis.Spraying the socks and shoes with sulconazole nitrate spray 1% would reduce the recurrence of tinea pedis.
作者
王美芳
李邻峰
程海燕
陈泽宇
田可
WANG Mei-fang, LI Lin-feng, CHENG hai-yan, CHEN Ze-yu, TIAN Ke(Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China)
出处
《中国真菌学杂志》
CSCD
2018年第3期164-167,共4页
Chinese Journal of Mycology
关键词
足癣
复发
硝酸硫康唑喷雾剂
鞋袜喷药
tinea pedis
recurrence
sulconazole nitrate spray
spray the socks and shoes
