摘要
目的:探讨宫颈癌同步放化疗患者接受营养干预前后免疫应答、毒副反应的变化。方法:选取2016年5月~2017年9月间在本院进行同步放化疗的原发性宫颈癌患者160例作为研究对象,回顾营养干预方案并将其分为接受常规营养支持的对照组83例、接受针对性营养干预的营养干预组77例。对比两组干预前后Th1/Th2免疫指标、体液免疫指标含量以及骨髓抑制相关指标水平的差异。结果:干预前,两组Th1/Th2免疫指标、体液免疫指标含量以及骨髓抑制相关指标水平的差异无统计学意义(P>0.05)。干预后,营养干预组血清中IL-2、IFN-γ、IL-4、IL-6的含量低于对照组;血清中IgA、IgM、IgG、C3、C4的含量高于对照组;外周血中WBC、RBC、Hb、PLT的水平高于对照组(P<0.05)。结论:营养干预可有效优化宫颈癌同步放化疗患者的免疫状态并减轻骨髓抑制反应。
Objective： To investigate the changes of immune response and side effects before and after nutritional intervention in cervical cancer patients with concurrent radiochemotherapy. Methods： A total of 160 patients with primary cervical cancer who received concurrent radiochemotherapy in our hospital between May 2016 and September 2017 were selected as the research subjects, and their nutritional intervention plans were reviewed and used to divide the patients into the control group （ n =83） who accepted conventional nutritional support and the nutritional intervention group （ n =77） who accepted targeted nutritional intervention. The differences in the contents of Th1/Th2 immunity indexes and humoral immunity indexes as well as the levels of bone marrow suppression-related indexes were compared between the two groups before and after intervention. Results： Before intervention, the differences in the contents of Th1/Th2 immunity indexes and humoral immunity indexes as well as the levels of bone marrow suppression-related indexes were not statistically significant between the two groups （ P 〉0.05）. After intervention, serum IL-2, IFN-γ, IL-4 and IL-6 contents of nutritional intervention group were lower than those of control group; serum IgA, IgM, IgG, C3 and C4 contents were higher than those of control group; peripheral blood WBC, RBC, Hb and PLT levels were higher than those of control group （ P 〈0.05）. Conclusion： Nutritional intervention can effectively optimize the immune status and reduce the bone marrow suppression reaction in cervical cancer patients with concurrent radiochemotherapy.
作者
陈英
CHENG Ying(Department of Obstetrics and Gynecology,Zigong Third People’s Hospital,Zigong 643000,Sichuan,China)
出处
《海南医学院学报》
CAS
2018年第13期1280-1283,共4页
Journal of Hainan Medical University
基金
四川省医学会课题项目(Q150124)~~
关键词
宫颈癌
营养干预
免疫应答
毒副反应
Cervical cancer
Nutritional intervention
Immune response
Side effects
