摘要
目的:分析血管性痴呆患者外周血白细胞介素-2(IL-2)、白细胞介素-9(IL-8)与IFN-γ的表达及其临床意义。方法:选取2017年1月~2017年11月90例血管性痴呆患者为观察组,并以同期行健康体检的90例无智能障碍成人为对照组,分别采用酶联免疫双抗体夹心法检测并比较两组受检者的IL-2、IL-8与γ干扰素(IFN-γ),并评估血管性痴呆同三项指标表达的相关性。结果:观察组IL-2水平为(0.67±0.25)pg/μl,IL-8水平为(0.29±0.17)pg/μl,IFN-γ水平为(187.42±8.21)pg/ml,与对照组比较,差异具有统计学意义(P<0.05)。结论:血管性痴呆患者的外周血IL-2、IL-8与IFN-γ等细胞因子表达同健康成人具有显著差异,进而表现在血管性痴呆发病及发展过程中受到了机体炎性反应与细胞免疫功能的影响。
Objective To discuss the expression and significance of peripheral blood interleukin IL-2,IL-8 and IFN-γ in patients with vascular dementia. Method 90 patients of vascular dementia were selected from January 2017 to November 2017 in our hospital as the observation group. At the same time,90 healthy adults without mental retardation were selected as the control group. The levels of interleukin-2（ IL-2）,interleukin-8（ IL-8） and interferon gamma（ IFN-γ） in the two groups were detected and compared by enzyme-linked immunosorbent assay（ ELISA）. The correlation of vascular dementia with three indexes of expression was evaluated. Results In observation group,the level of IL-2 was（ 0. 67 ± 0. 25） pg/μL,and the level of IL-8 was（ 0. 29 ± 0. 17） pg/μl,and the level of IFN-γ was（ 187. 42 ± 8. 21） pg/ml. These indexes were statistically significant compared with those of the control group（ P〈0. 05）. Conclusion The expression of IL-2,IL-8 and IFN-γ in peripheral blood of patients with vascular dementia is significantly different from that of healthy adults,The effects of inflammatory response and cellular immune function in the pathogenesis and development of vascular dementia are presented.
作者
邓伟华
邓彦
叶峰
彭文宏
DENG Wei-hua;DENG Y-an;YE Feng(The first people＇s Hospital of Shaoguan,Shaoguan 512000,China)
出处
《吉林医学》
CAS
2018年第7期1261-1263,共3页
Jilin Medical Journal
基金
韶关市卫生计生科研立项课题[课题编号:Y17077]
