摘要
慢性非传染性疾病（以下简称慢性病）是人类健康最大的挑战之一。近年来,随着经济快速增长,我国的慢性病发病率迅速上升,并呈现年轻化趋势。目前我国明确诊断的慢性病患者超过2.6亿人,占我国人群死因构成的85%、疾病负担的69%,已经成为严重的公共卫生问题和社会问题。脏器纤维化是器官组织内纤维结缔组织增多和实质细胞减少的病理变化,是多种慢性疾病的共同病理特征。心、肝、肺和肾等实质脏器纤维化是导致脏器功能衰竭。
Organ fibrosis is a common pathogenetic change of parenchymal organs under chronic conditions,characterized by increased fibrous connective tissues and reduced parenchymal cells. The essence of renal fibrosis is the＂repair of scars＂after renal tissue damage. It involves a loss of renal parenchyma cells,activation of myofibroblasts,deposition of extracellular matrix,imbalance of metabolism and abnormal interactions with organs. Hepatic fibrosis is a kind of repair response induced by various chronic hepatic diseases,including viral hepatitis and metabolic liver disease,and it is the common pathological basis of end-stage hepatic disease. Pulmonary fibrosis is a progressive and fatal inflammatory interstitial lung disease,characterized by inflammatory destruction and extracellular matrix deposition. Myocardial fibrosis is a process of pathological repair after a variety of injuries caused by hypertension,hypertrophic cardiomyopathy,viral cardiomyopathy,valve disorders,myocardial ischemia,diabetes,obesity and other metabolic abnormalities. Organ fibrosis indicates some common pathogenesis,but the exact mechanisms differ from organs and still need further investigation to identify biomarkers for early diagnosis and to devise drugs specifically for fibrosis. This article comprehensively summarizes the recent developments in organ fibrosis over the last 3 years,including underlying mechanisms and urgent scientific issues remained.
作者
韩敏
聂静
李萃
孙瑞娟
董尔丹
HAN Min;NIE Jing;LI Cui;SUN Rui-juan;DONG Er-dan(Department of Health Sciences,National Natural Science Foundation of China,Beijing 100085,China;Institurte of Vascular Medicine,Peking University Third Hospital,Beijing,100191,China;Department of Nephrology,Nanfang Hospital,Nanfang Medical University,Guangzhou 510515,China)
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2018年第8期1518-1526,共9页
Chinese Journal of Pathophysiology
关键词
脏器纤维化
发病机制
科学问题
Organ fibrosis
Pathogenesis
Scientific issues
