摘要
目的研究探讨自身抗体和肝功能检测在鉴别诊断自身免疫性肝病所起到的意义,以提高临床上对自身免疫性肝病诊断的准确率和速度。方法方便选取2016年3月—2017年11月在该院接受治疗的45例自身免疫性肝病的患者和45例病毒性肝炎的患者作为该次研究对象。对所有患者检测自身抗体和肝功能检,对经检查的入组对象的最终检查结果,进行回顾性的统计分析。结果将两组被研究对象检查结果整理、分析,进行比较,可见:自身免疫组的自身抗体指标的检出率均比病毒性肝炎组的检出率高,比较差异有统计学意义(P<0.05)。自身免疫性肝病组ANA、AMA-M2、LKM-1、SMA分别占35例(77.78%)、23例(51.11%)、22例(48.89%)、33例(73.33%),病毒性肝炎组ANA、AMA-M2、LKM-1、SMA分别占23例(51.11%)、7例(15.56%)、9例(20.00%)、21例(46.67%),(χ~2=6.983、12.800、8.316、6.667)。将两组肝功指标进行比较,自身免疫性肝病组的AST、ALT、ALP分别是(201.92±42.18)、(258.75±71.34)、(301.79±34.11)U/L,各指标数值均高于病毒性肝炎组(t=22.712、16.559、44.822),比较差异有统计学意义(P<0.05)。结论通过自身抗体和肝功能联合检测的方法对患者进行相关检查,不仅诊断准确、科学,而且所耗时间短,值得在临床诊断过程中进行推广和应用。
Objective This paper tries to study the significance of autoantibodies and liver function tests in the differential diagnosis of autoimmune liver disease in order to improve the accuracy and speed of clinical diagnosis of autoimmune liver disease. Methods 45 patients with autoimmune liver disease and 45 patients with viral hepatitis who were treated in this hospital from March 2016 to November 2017 were convenient selected as the subjects of this study. All patients were tested for autoantibodies and liver function tests, and the final examination results of the examined subjects were retrospectively analyzed. Results By collating and analyzing the results of the two groups of subjects, it can be seen that the detection rate of autoantibodies in the autoimmune group was higher than that of the viral hepatitis group, and there was a statistically significant difference（P〈0.05）. ANA, AMA-M2, LKM-1, and SMA accounted for 35 cases（77.78%）, 23 cases（51.11%）, 22 cases（48.89%）, and 33 cases（73.33%） in the autoimmune liver disease group, and ANA, AMA-M2, and LKM-1, SMA in the viral hepatitis group, respectively accounted for 23 cases（51.11%）, 7 cases（15.56%）, 9 cases（20.00%）, 21 cases（46.67%）（χ~2=6.983,12.800, 8.316, 6.667）, respectively. Comparing the two groups of liver function indicators, the AST, ALT, and ALP of the autoimmune liver disease group were（201.92 ±42.18）,（258.75 ±71.34）, and（301.79 ±34.11）U/L, respectively. The value of each index was higher than that of the virus. In the hepatitis group（t=22.712, 16.559, 44.822）, respectively, with statistically significant differences（P〈0.05）. Conclusion Through the combined detection of autoantibodies and liver function, the relevant examinations of patients are not only accurate, scientific, but also short in time, which is worthy of promotion and application in clinical diagnosis.
作者
张丽琼
ZHANG Li-qiong(Department of Clinical Laboratory,Putian First Hospital,Putian,Fujian Province,351100 China)
出处
《中外医疗》
2018年第18期60-61,75,共3页
China & Foreign Medical Treatment
关键词
肝病
自身免疫
自身抗体
肝功能
检测方法
应用意义
Liver disease
Autoimmune
Autoantibodies
Liver funetion
Deteetion method
Applieation signifieane
