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低甲状腺素血症与妊娠期糖尿病的相关性分析 被引量:5

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摘要 目的分析低甲状腺素血症与妊娠期糖尿病(GDM)的相关性,为临床治疗提供相关依据。方法选取2016年1-12月来该院进行规律产检的4 138例孕妇作为研究对象,根据甲状腺功能进行筛选,将81例(1.96%)低甲状腺素血症孕妇设置为低甲状腺素血症组,排除其他甲状腺疾病孕妇后,以剩余的甲状腺功能正常的4 057例孕妇为正常组,比较两组甲状腺相关激素水平以及血糖情况。再参照《中华妇产科学》进行葡萄糖耐量试验分为GDM组(60例)和非GDM组(3 537例),对比GDM组和非GDM组甲状腺水平,最后将所有孕妇血清游离甲状腺素(FT_4)水平与空腹血糖(FPG)、餐后2 h血糖(2h PG)、糖化血红蛋白(Hb Alc)水平进行Pearson相关性分析。结果低甲状腺素血症组和正常组组间血清促甲状腺激素(TSH)和游离三碘甲状腺原氨酸(FT3)水平比较,差异均无统计学意义(均P>0.05),低甲状腺素血症组血清FT_4水平明显低于正常组(P<0.05)。低甲状腺素血症组血清FPG、2h PG和Hb Alc水平均高于正常组(P<0.05),且GDM患病率明显高于正常组(P<0.05)。GDM组和非GDM组组间TSH和FT3水平比较,差异均无统计学意义(均P>0.05),GDM组血清FT_4水平明显低于非GDM组(P<0.05)。FT_4水平与FPG、2h PG、Hb Alc均呈负相关(P<0.05)。结论低甲状腺素血症会增加孕妇患GDM的危险,为避免不良妊娠结局,应及时进行治疗。
出处 《中国妇幼保健》 CAS 2018年第15期3387-3389,共3页 Maternal and Child Health Care of China
基金 河北省卫生厅课题项目(20150875)
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