摘要
目的观察重组人生长激素（rhGH）应用于重度烧伤患儿的效果。方法回顾性分析2012年4月—2016年12月笔者单位烧伤科收治的符合入选标准的94例重度烧伤患儿的临床资料。根据是否应用rhGH治疗分为rhGH组50例、对照组44例。对照组患儿采用常规治疗，rhGH组患儿在常规治疗基础上增加rhGH治疗，伤后3～5 d开始用药，用药剂量为0.2～0.4 U·kg－1·d－1，采用皮下注射，疗程为（11±5）d。比较2组患儿伤后2周时血浆白蛋白、前白蛋白水平，伤后2周时心率、丙氨酸转氨酶（ALT）、血肌酐水平，植皮手术次数、住院时间、住院总治疗费用，脓毒症发生情况和病死情况。对数据行独立样本t检验、Mann-Whitney U检验、Fisher确切概率法检验。结果（1）伤后2周时，rhGH组患儿血浆白蛋白水平为（36±4）g/L、前白蛋白水平为（94±34）g/L，明显高于对照组患儿的（33±4）、（73±20）g/L（t＝3.666、3.401，P〈0.05）。（2）伤后2周时，rhGH组患儿心率为（123±11）次/min，慢于对照组患儿的（130±14）次/min（t＝2.839，P〈0.05）；2组患儿ALT水平比较，差异无统计学意义（Z＝0.868，P〉0.05）。伤后2周时，2组患儿血肌酐水平均在正常范围内。（3）rhGH组患儿植皮手术次数为（0.3±0.5）次，明显少于对照组患儿的（0.5±0.6）次（Z＝2.234，P〈0.05）；rhGH组患儿住院时间为（22±8）d，较对照组患儿的（28±10）d缩短（t＝2.837，P〈0.05）；rhGH组患儿住院总治疗费用为（4.1±1.5）万元，明显少于对照组患儿的（5.3±2.5）万元（t＝2.878，P〈0.05）。（4）rhGH组患儿中有1例发生脓毒症，对照组患儿中有2例，2组比较，差异无统计学意义（P〉0.05）。2组均未出现死亡病例。结论rhGH治疗重度烧伤患儿可以纠正伤后低蛋白血症，改善心脏功能，减少植皮手术次数和住院治疗费用，缩短住院时间，对肾脏和�
ObjectiveTo observe the clinical effects of recombinant human growth hormone （rhGH） on children with severe burn.MethodsClinical data of 94 children with severe burn, hospitalized in our burn unit from April 2012 to December 2016, conforming to the study criteria, were retrospectively analyzed. According to the use of rhGH, children were divided into rhGH group （n=50） and control group （n=44）. Children in control group received conventional treatment, while children in rhGH group received both conventional and rhGH treatment. The rhGH treatment was started 3 to 5 days post injury in dosage of 0.2-0.4 U·kg-1·d-1, by way of subcutaneous injection, and the course of treatment was （11±5） d. The plasma albumin and prealbumin levels, heart rate, alanine aminotransferase （ALT）, and serum creatinine level in 2 weeks post injury, times of skin grafting operation, hospitalization time, total hospitalization treatment cost, and sepsis and death of children were compared between the 2 groups. Data were processed with independent sample t test, Mann-Whitney U test, and Fisher′s exact test.Results（1） In 2 weeks post injury, the plasma albumin level [（36±4） g/L] and prealbumin level [（94±34） g/L] of children in rhGH group were significantly higher than those in control group [（33±4） and （73±20） g/L, t=3.666, 3.401, P〈0.05]. （2） In 2 weeks post injury, the heart rate of children in rhGH group was （123±11） times per minute, which was slower than （130±14） times per minute of children in control group （t=2.839, P〈0.05）. There was no significant difference in ALT level of children between the 2 groups （Z=0.868, P〉0.05）. The blood creatinine levels of children in the 2 groups were within normal range. （3） The times of skin grafting operation of children in rhGH group was 0.3±0.5, which was significantly less than 0.5±0.6 in control group （Z=2.234, P〈0.05）. The hospitalization time of children in rhGH group was （22±8） days, which was shorter
作者
褚志刚
李泽
王爱华
阮琼芳
吴红
阮晶晶
谢卫国
Chu Zhigang;Li Ze;Wang Aihua;Ruan Qiongfang;Wu Hong;Ruan Jingjing;Xie Weiguo(Department of Burns,Tongren Hospital of Wuhan University ＆ Wuhan Third Hospital,Wuhan 430060,Chin)
出处
《中华烧伤杂志》
CAS
CSCD
北大核心
2018年第8期522-525,共4页
Chinese Journal of Burns
基金
武汉市科学技术计划（2015070404010214）武汉市卫生和计划生育委员会临床医学科研项目（WX14B14）
关键词
烧伤
人生长激素
伤口愈合
Burns
Human growth hormone
Wound healing
