摘要
目的探讨思美泰联合熊去氧胆酸（UDCA）治疗对妊娠期肝内胆汁淤积症（ICP）患者血清指标及母婴结局的影响。方法选择2016年5月至2017年9月ICP患者92例，随机分为两组，每组各46例。对照组给予思美泰治疗，观察组在此基础上联合给予UDCA治疗．连续治疗2周后对两组进行疗效评定。结果两组治疗后血清ALT、AST、TBA、TBIL水平均较治疗前显著下降（P〈0．05）；观察组治疗后血清ALT、AST、TBA、TBIL水平明显低于对照组（P〈0．05）。两组治疗后瘙痒评分均有明显降低（P〈005）；观察组治疗后瘙痒评分明显低于对照组（P〈005）。观察组产后出血、羊水污染、宫内窘迫、新生儿窒息、早产发生率均低于对照组，其中产后出血、早产发生率比较差异有统计学意义（P〈0．05）。结论思美泰联合熊去氧胆酸治疗ICP可显著改善患者的肝功能，改善母婴结局，值得推广应用。
Objective To investigate the effect of Transmetil combined with ursodeoxycholic acid on serum indexes and maternal and neonatal outcomes in patients with intrahepatic cholestasis of pregnancy （ICP）. Methods 92 patients with ICP were treated in our hospital from May 2016 to September 2017. They were divided into two groups by random numbers, with 46 cases in each group. The control group was treated with Transmetil, and the observation group was given Transmetil combined with ursodeoxychohc acid. After 2 weeks of continuous treatment, the curative effect was evaluated in the two groups. Results The serum levels of ALT, AST, TBA and TBIL in the two groups were significantly lower than those before treatment （ P〈0.05 ） . The levels of serum ALT, AST, TBA and TBIL in the observation group were significantly lower than those in the control group （ P〈0.05 ） . After treatment, the pruritus score of the two groups was significantly lower （P〈0.05） , and the itching score of the observation group was significantly lower than that of the control group （ P〈0.05 ） . The incidence of postpartum hemorrhage, amniotic fluid pollution, Miyamauchi Sako, neonatal asphyxia and premature delivery in the observation group were lower than those in the control group, and the incidence of postpartum hemorrhage and premature delivery was statistically significant （ P〈0.05 ） . Conclusion The treatment of ICP with ursodeoxycholic acid （ ursodeoxycholic acid ） with Transmetil can significantly improve the fiver function and improve the outcome of mother and infant. It is worth popularizing.
出处
《浙江临床医学》
2018年第9期1544-1545,共2页
Zhejiang Clinical Medical Journal
关键词
思美泰
熊去氧胆酸
妊娠期肝内胆汁淤积症
血生化指标
母婴结局
Transmetil
Ursodeoxycholic acid
Intrahepatic cholestasis of pregnancy
Blood gas index
Maternal and infant outcome
