摘要
目的研究在类风湿性关节炎中采取自身抗体、HLA-DR4、HLA-DR53检测的临床价值与意义。方法该次纳入分析的对象为2015年8月—2017年8月期间该院参与诊治的33例类风湿性关节炎患者,将其作为实验组,选取同期来该院进行体检的33名健康体检人员作为参照组,均实行自身抗体检测、HLA-DR4、HLA-DR53检测,比较两组受检人员的相关检测结果。结果实验组类风湿性关节炎患者HLA-DR53的54.54%、HLA-DR4的42.42%、ANA的63.63%、AKA的36.36%、anti-CCP的84.84%、APF的45.45%、anti-Sa的36.36%等对比参照组,差异有统计学意义(P<0.05)。检测类风湿性关节炎患者之后特异度最高指标为APF、anti-Sa、anti-CCP,约登指数与敏感性最高指标为anti-CCP。结论自身抗体检测与HLA-DR4、HLA-DR53检测之间的一致性比较高,采取联合检测,有利于临床诊断类风湿性关节炎疾病。
Objective This paper tries to study the clinical value and significance of autoantibody detection, HLA-DR4 and HLA-DR53 detection in rheumatoid arthritis. Methods The subjects included in this analysis were 33 patients with rheumatoid arthritis who participated in the treatment from August 2015 to August 2017 in this hospital, used as the experimental group and 33 healthy physical examination personnel who had physical examination in this hospital during the same period as the reference group, autoantibody detection, HLA-DR4, and HLA-DR53 detection were performed, and the results of the two groups of subjects were compared. Results In the experimental group, 54.54% of patients with rheumatoid arthritis were HLA-DR53, 42.42% of HLA-DR4, 63.63% of ANA, 36.36% of AKA, 84.84% of anti-CCP, 45.45% of APF, and 36.36% of anti-Sa. Comparing with the reference group, statistical significance existed（P〈0.05）. The highest specificity indicators for patients with rheumatoid arthritis were APF, anti-Sa, and anti-CCP. The anti-CCP was the highest index of sensitivity. Conclusion The consistency between autoantibody detection and detection of HLA-DR4 and HLA-DR53 is relatively high, and joint detection is beneficial to clinical diagnosis of rheumatoid arthritis.
作者
吴红
蒋毅
游苘霞
邹庆华
石颖
牟方祥
WU Hong;JIANG Yi;YOU Qing-xia;ZOU Qing-hua;SHI Ying;MOU Fang-xiang(Department of Integrated Traditional Chinese and Western Medicine,the First Affiliated Hospital of Army Medical University,Chongqing,400038 Chin)
出处
《系统医学》
2018年第8期56-58,共3页
Systems Medicine
