摘要
Yes相关蛋白(YAP)/转录共激活因子PDZ结合基序(TAZ)/作为Hippo信号通路级联的下游效应因子,在器官生长、组织再生、细胞增殖等中具有关键调控作用。在哺乳动物细胞中,Hippo通路的激酶级联反应通过磷酸化YAP/TAZ来抑制YAP/TAZ的活性,从而调控器官的大小和肿瘤的形成。上皮-间充质转化作为肿瘤转移的首发事件,是肿瘤发展的关键因素,而YAP/TAZ在调控肿瘤细胞上皮-间充质转化中具有重要作用。而作为核心的YAP/TAZ必将成为癌症和再生药物中最有吸引力的治疗靶点。
As a downstream effector of Hippo signaling pathway,Yes-associated protein（YAP）/transcriptional co-activator with PDZ-binding motif（TAZ） plays a key regulatory role in organ growth,tissue regeneration and cell proliferation.In mammalian cells,the kinase cascade of the Hippo pathway inhibits YAP/TAZ activity by phosphorylating YAP/TAZ to regulate organ size and tumor formation. Epithelial-mesenchymal transition（EMT）,as the first incident of tumor metastasis,is the key to tumor development,YAP/TAZ plays an important role in the regulation of EMT of tumor cells. The core YAP/TAZ will certainly become the most attractive therapeutic target for cancer and regenerative medicine.
作者
修子涵
唐旭东
XIU Zihan;TANG Xudong(Institute of Biochemistry and Molecular Biology,Collaborative Innovation Center for Antitumor Active Substance Research and Development,Guangdong Medical University,Zhanjiang 524023,Chin)
出处
《医学综述》
2018年第14期2787-2791,2796,共6页
Medical Recapitulate
基金
国家自然科学基金(81372511)
广东省自然科学基金(2017A030313539)
广东省产业技术开发研究与开发专项资金项目(2013B031100002)
广东省“扬帆计划”培养高层次人才项目(201635011)
广东省科技计划项目(20130324c)
