摘要
多种眼部组织可形成新生血管,如角膜、脉络膜和视网膜等。而病理性新生血管的产生是导致视力损害甚至致盲的重要原因之一。目前临床上对于眼部新生血管的治疗方式主要有激光光凝治疗及抗血管内皮生长因子药物治疗等。以往关于该疾病发生机制方面的研究主要集中于该疾病相关的生物活性因子。miRNAs可靶向作于相应的mRNA并使mRNA表达下调,从而调控相关生物活性因子的表达,影响眼部新生血管疾病的发生、发展。
Numerous ocular diseases are related to angiogenesis,including neovascularization of cornea,choroid and retina. Pathological angiogenesis is a leading cause of visual impairment and blindness. Clinical treatments for the diseases include laser-induced thermotherapy and anti-vascular endothelial growth factor drugs. Most former researches focused on the relations between bioactive factors and the diseases. MiRNAs can be targeted to the corresponding mRNA and reduce the expression of mRNA,thus regulating the expression of related bioactive factors and affecting the occurrence and development of ocular neovascularization.
作者
丁一珩
张红
DING Yiheng;ZHANG Hong(Department of Ophthalmology Hospital,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处
《医学综述》
2018年第14期2765-2770,共6页
Medical Recapitulate
基金
国家自然科学基金(81671844)
