摘要
目的本研究旨在探索RA患者中RDW与贫血、炎性指标、疾病活动之间联系。方法回顾性分析2012~2014年期间北京协和医院83例连续收住院的RA患者的红细胞沉降率(ESR)、超敏-C反应蛋白(hs-CRP)、抗环瓜氨酸多肽(CCP)抗体、类风湿因子(RF)和红细胞分布宽度(RDW),并连续收集重庆市第九人民医院2016年5月体检的83例健康成人的ESR、hs-CRP、抗CCP抗体、RF和RDW作为对照组,进行组间比较。RA患者组按照疾病活动性和是否存在贫血进一步分为亚组,进行亚组间比较分析。结果 RA伴贫血患者的RDW值(15.5±2.4)明显高于RA不伴贫血患者(12.9±1.5,P=0.000)和正常体检者(11.9±0.3,P=0.000);活动期RA患者的RDW值高于非活动期的RA患者(14.8±2.2 vs 13.0±1.5,P=0.000);hs-CRP、抗CCP与RDW值之间呈正相关,是RDW值的独立影响因素(P<0.05)。结论 RDW值对RA预后的影响可能和RDW与hs-CRP、抗CCP的正相关性有关,可能是与RA患者疾病活动程度及预后有关的指标。
Objective This study is designed to investigate the relationships between RDW and anemia, inflammation indices, and disease activity. Methods Retrospectively collected the erythrocyte sediment rate（ESR）, high-sensitive C-reactive protein（hs-CRP）, anti-cyclic citrullinated protein antibody （anti-CCP）, rheumatoid factor （RF） and RDW of 83 RA patients hospitalized consecutively during 2012 to 2014 in Peking Union Medical College Hospital as study group. These patients were sub-divided into patients with/without active disease and patients with/without anemia. We consecutively collected ESR, hs-CRP, anti-CCP, RF, and RDW of 83 healthy controls from the Ninth people＇s hospital in Chongqing. Comparisons were made between study group and control group, and between sub-groups. Results RDW of RA patients with anemia （15.5±2.4） was significantly higher than RA patients without anemia （12.9±1.5, P=0.000） and healthy controls （11.9±0.3, P=0.000）. RDW of RA patients with active disease was significantly higher than RA patient without active disease （14.8±2.2 vs 13.0±1.5, P=0.000）. Positive correlations were found between RDW and hs-CRP, and between RDW and anti-CCP. Hs-CRP and anti-CCP are found to be independent influencing factors of RDW by multivariate linear regression. Conclusion The effect of RDW to prognosis of RA maybe related with the positive correlations between RDW and hs-CRP, and between RDW and anti-CCP. RDW might become a new index relating to the disease activity and prognosis of RA.
作者
江维
贺雄
杜金万
胡春蓉
李菁
Jiang Wei;He Xiong;Du Jinwan(Department of Rheumatology and Clinical Immunology,Peking Union Medical College Hospital,Peking Union Medical College and Chinese Academy of Medical Sciences,Key Laboratory of Rheumatology and Clinical Immunology,Ministry of Education,Beijing 100730,China)
出处
《医学研究杂志》
2018年第7期27-31,共5页
Journal of Medical Research
基金
国家自然科学基金资助项目(81401333)
关键词
类风湿关节炎
红细胞分布宽度
贫血
炎性指标
Rheumatoid arthritis
Red cell distribution width
Anemia
Indices of inflammation
