摘要
目的探讨血清嗜酸性粒细胞阳离子蛋白(ECP)、C反应蛋白(CRP)和呼出气一氧化氮(FeNO)联合检测在支气管哮喘诊治中的应用。方法选取2014年10月至2016年10月唐山市协和医院接诊的50例支气管哮喘患者作为研究对象,并选择同期在该院接受体检的50例健康人员作为对照组。使用酶联免疫吸附试验法检测血清ECP、CRP的表达,使用FeNO检测仪检测FeNO水平。比较支气管哮喘组和对照组血清ECP、CRP、FeNO的表达,并比较不同病情程度支气管哮喘患者血清ECP、CRP、FeNO的表达;支气管哮喘组在接受3个月的对症治疗后,比较不同疗效结果患者血清ECP、CRP、FeNO的表达。结果支气管哮喘组血清ECP、CRP、FeNO水平[(15.86±1.47)ng/L、(4.87±0.52)mg/L、(61.23±11.52)ppb]均明显比对照组高[(6.62±0.63)ng/L、(1.04±0.23)mg/L、(23.58±3.40)ppb],差异有统计学意义(P<0.05);急性发作期支气管哮喘患者血清ECP、CRP、FeNO[(18.56±1.85)ng/L、(5.74±0.70)mg/L、(66.93±10.62)ppb]明显比缓解期患者高[(12.34±1.47)ng/L、(3.69±0.37)mg/L、(54.54±8.02)ppb],差异有统计学意义(P<0.05);支气管哮喘患者在治疗3个月后,临床控制28例,部分控制18例,未控制4例,临床控制组血清ECP、CRP和FeNO明显低于部分控制组及未控制组,差异有统计学意义(P<0.05)。结论通过联合检测支气管哮喘患者血清ECP、CRP、FeNO的表达有助于了解疾病严重程度,在疾病的早期诊治中具有积极意义。
Objective To study the application of combined detection of serum eosinophil cationic protein（ECP）,C reactive protein（CRP）and fractional exhaled nitric oxide（FeNO）in the bronchial asthma.Methods 50 patients of bronchial asthma who received therapy from October 2014 to October 2016 in Tangshan city union hospital were selected as research objects,and selected 50 healthy people who received physical examination at the same time in the hospital as control group.The expression of serum ECP and CRP was detected by enzyme-linked immunosorbent assay,and the FeNO concentration was detected using FeNO detector.The expressions of serum ECP,CRP and FeNO between the bronchial asthma group and the control group were compared,and the expressions of serum ECP,CRP and FeNO in patients with different severity of bronchial asthma were compared;the bronchial asthma group received 3 months of symptomatic treatment,The expression of serum ECP,CRP and FeNO in patients with different therapeutic effects were compared.ResultsThe serum ECP,CRP and FeNO in the bronchial asthma group [（15.86±1.47）ng/L,（4.87±0.52）mg/L,（61.23±11.52）ppb]were significantly higher than those in the control group[（6.62±0.63）ng/L,（1.04±0.23）mg/L,（23.58±3.40）ppb],the difference was statistically significant（P〈0.05）;The serum ECP,CRP and FeNO in the acute attack of bronchial asthma[（18.56±1.85）ng/L,（5.74±0.70）mg/L,（66.93±10.62）ppb]were higher than those in the remission stage[（12.34±1.47）ng/L,（3.69±0.37）mg/L,（54.54±8.02）ppb],the difference was statistically significant（P〈0.05）;The patients with bronchial asthma were treated 3 months later,clinical control in 28 cases,partial control in 18 cases,uncontrolled in 4 cases,the serum ECP,CRP and FeNO in the clinical control group were significantly lower than those in the partial control group and the uncontrolled group,the difference was statistically significant（P〈0.05）.Conclusion The combined detection of serum ECP,CRP and FeNO e
作者
汪静
郑丽颖
李卓隽
李强
刘运秋
WANG Jing;ZHENG Liying;LI Zhuojun;LI Qiang;LIU Yunqiu(Department of Respiratory Medicine,Tangshan City Union Hospital,Tangshan,Hebei 063000,Chin;Department of Respiratory Medicine,Kailuan General Hospital,Tangshan,Hebei 063000,China)
出处
《国际检验医学杂志》
CAS
2018年第13期1569-1572,共4页
International Journal of Laboratory Medicine
基金
河北省卫生和计划生育委员会医学科学研究课题(20171446)
