摘要
目的 Meta分析我国孕期风疹病毒IgM检测阳性率、IgM阳性率与孕产次的关系,以及IgM阳性率与早期流产的相关性。方法通过计算机检索Cochrane Library、PubMed、CBMdisc、CNKI、维普、万方等数据库,时限从建库至2017年6月。选定关键词,查找孕期风疹病毒IgM检测相关研究。按照纳入与排除标准选择文献,提取资料,利用STATA数据处理软件进行Meta分析。结果最终纳入文献9篇,汇总后总样本量为53 270例,其中阳性例数为1 923例,总阳性率为3.61%。孕期风疹病毒IgM阳性与孕产次关系共纳入文献5篇,统计结果显示多次妊娠会增加孕妇风疹病毒IgM阳性率,OR及95%CI为[0.316(0.210,0.475)],且差异有统计学意义(P<0.001)。孕期风疹病毒IgM阳性与早期流产关系共纳入文献4篇,结果显示IgM阳性者发生早期流产的风险要明显大于IgM阴性孕妇,OR及95%CI为[3.184(1.874,5.410)],且差异有统计学意义(P<0.001)。结论应加强孕期风疹病毒筛查,预防出生缺陷及不良妊娠结局。
Objective：To evaluate the positive rate of anti-rubella IgM antibody in early pregnancy,and the relationship between the positive rate of anti-rubella IgM antibody and gestational times as well as early abortion.Methods： Databases including Cochrane Library,PubMed,CBM,CNKI,VIP and Wanfang Databases were searched to identify the document related to the detection of anti-rubella IgM antibody during pregnancy from the establishment of databases to June 2017.Meta-analyses were performed by using the STATA software after the selection of studies,extraction of data and assessment of quality based on the inclusive and exclusive criteria.Results：Nine papers including 53 270 women were selected.Among them,1 923（3.61%）women with positive anti-rubella IgM antibody were found.Five papers related the positive rate of anti-rubella IgM antibody with gestational times were included.The statistical results showed that the positive rate of antirubella IgM antibody was increased with the gestational times[OR=0.316;95% CI（0.210,0.475）;P〈0.001].Four papers with the relationship between the positive rate of anti-rubella IgM antibody and early abortion were included.The results showed that the risk of early abortion was significantly higher in pregnant women with positive anti-rubella IgM antibody than IgM negative pregnant women[OR=3.184;95% CI（1.874,5.410;P〈0.001].Conclusions：Serologic screening on rubella virus in pregnant women should be strengthened to prevent birth defects and adverse pregnancy outcomes.
作者
李学敬
茅群霞
裴开颜
LI Xue-jing;MAO Qun-xia;PEI Kai-yan(Social Medicine Research Center,National Research Institute for Family Planning,Beijing 100081;Peking Union Medical College Graduate School,Beijing 100730)
出处
《生殖医学杂志》
CAS
2018年第7期647-652,共6页
Journal of Reproductive Medicine
基金
国家科技支撑计划课题(2012BAI41B08)
