摘要
背景:髋臼发育不良患者常合并髋臼骨质增生、股骨头坏死,会使股骨头中心点位置发生改变,这样在使用骨盆X射线成像测量影像学诊断指标——中心边缘角、髋臼角、头臼指数时就会存在误差,从而影响髋臼发育不良诊断的准确性。目的:试验提出了3种新的X射线指标测量方法,分别测量股骨头外移指数、上移指数、泪滴基线外移指数的变化,这些结果指标均用相对比值表示,可规避测量角度带来诊断成人髋臼发育不良导致的误差,以期对髋臼发育不良做出更准确的诊断。方法:试验在中国河北省,河北医科大学第三医院完成。纳入行骨盆正位X射线片检查的成人患者200例,男女各100例,采用Photoshop CS5软件对X射线图像进行健侧及患侧影像学指标测量及分析。试验的主要观察指标为股骨头外移指数对成人髋臼发育不良诊断的敏感度;次要观察指标为股骨头外移指数对成人髋臼发育不良诊断的特异度、阳性预测值、阴性预测值、阳性似然比、阴性似然比及诊断正确率,股骨头上移指数、泪滴基线外移指数对成人髋臼发育不良诊断的敏感度特异度,特异、阳性预测值、阴性预测值、阳性似然比、阴性似然比及诊断正确率,股骨头外移指数、上移指数、泪滴基线外移指数与中心边缘角、髋臼角、头臼指数的相关性,影响髋关节功能的危险因素Logistic回归分析结果。目前试验已得到241例骨盆正位X射线检查的男性患者的数据结果,显示患侧外移指数、上移指数、泪滴基线外移指数分别为(86.8±0.6)%,(75.8±2.0)%及(76.2±0.5)%,此3个指数与髋关节CE角、Sharp角及头臼指数具有一定相关性。试验经中国河北医科大学第三医院伦理委员会批准(批准单位:河北医科大学第三医院,批准号:KE2016-011-1)。研究符合世界医学会制定的《赫尔辛基宣言》的要求。参与者对试验方案和过程均知情�
BACKGROUND： Acetabular dysplasia often accompanies by acetabular bone hyperplasia and osteonecrosis of the femoral head. These pathological changes can alter the position of the center of the femoral head. Thus, measurement errors will be generated on the anteroposterior radiographs of the adult pelvis involving centre-edge angle, acetabular angle（Sharp angle）, and acetabular head index, eventually resulting in the inaccurate diagnosis of acetabular dysplasia.OBJECTIVE： To verify three novel X-ray indicators, including offshoring index（OFI）, moving up index（MUI） and teardrop baseline offshoring index（TBOI） of the femoral head. All data will be expressed as relative ratios, as we expect to make an accurate diagnosis through avoiding the generation of errors resulting from measurement angles. METHODS： A trial will be conducted at the Third Hospital of Hebei Medical University in China. Two hundred adult patients（100 females and 100 males） undergoing pelvic X-ray examinations will be enrolled as the study population. X-ray images of the affected and healthy pelvic sides will be measured and analyzed using Photoshop CS5 software. Primary outcome measure is the sensitivity of OFI of the femoral head for diagnosing adult acetabular dysplasia. Secondary outcome measures include the specificity, positive and negative predictive values, and positive and negative likelihood ratios of OFI of the femoral head for diagnosing adult acetabular dysplasia as well as the rate of correct diagnosis; specificity and sensitivity, positive and negative predictive values, and positive and negative likelihood ratios of MUI of the femoral head for diagnosis of adult acetabular dysplasia as well as the rate of correct diagnosis; specificity and sensitivity, positive and negative predictive values, and positive and negative likelihood ratios of TBOI of the femoral head for diagnosis of adult acetabular dysplasia as well as the rate of correct diagnosis; correlation of OFI, MUI and TBOI to centre-edge angle, Sharp a
作者
秦迪
胡世伟
李会杰
何丽英
吴啸波
吴涛
马文辉
韩永台
Qin Di;Hu Shi-wei;Li Hui-jie;He Li-ying;Wu Xiao-bo;Wu Tao;Ma Wen-hui;Han Yong-tai(the Third Hospital of Hebei Medical University,Shijiazhuang 050051,Hebei Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2018年第19期3039-3043,共5页
Chinese Journal of Tissue Engineering Research
基金
河北省医学科学研究重点课题计划项目(20180457)~~
