摘要
目的探讨儿童急性淋巴细胞白血病继发噬血细胞综合征的临床特征、预后及发生的可能原因。方法收集1例确诊的"急性淋巴细胞白血病"患儿继发"噬血细胞综合征"病例,回顾性分析其原发病、临床表现、实验室检查指标、治疗与转归特点,并复习相关文献。结果骨髓细胞学涂片诊断为急性淋巴细胞白血病ALL-L1,白细胞细胞免疫分型检测符合Common-BALL表型,原始及幼稚淋巴细胞比例占37.8%。噬血细胞综合征确诊后,按照HLH-2004化疗方案进行治疗,3个月后患儿死亡。结论儿童急性淋巴细胞白血病继发噬血细胞综合征来势凶险,临床表现各异,常伴有多脏器功能损害;常规治疗效果差,死亡率高。
Objective To investigate the clinical characteristics,prognosis and possible causes of the secondary hemophagocytic syndrome in children with acute lymphoblastic leukemia. Methods The primary disease,clinical manifestations,laboratory examination indicators,treatment and prognosis characteristics of a case confirmed was collected and the literatures reviewed. Results After the acute lymphoblastic leukemia of children was diagnosed to secondary hemophagocytic syndrome,HLH-2004 chemotherapy program implemented. The children died soon. Conclusion This disease is dangerous,with varied clinical manifestations and often accompanied by multiple organ dysfunction. The outcome are bad and mortality is high.
作者
刘超
李长钢
LIU Chao;LI Changgang(Zun yi Medical College in Zhuhai Campus,guangdong Zhuhai 519041,China;Children＇s Hospital of Shenzhen,guangdong Shenzhen 518038,China)
出处
《安徽医药》
CAS
2018年第7期1363-1365,共3页
Anhui Medical and Pharmaceutical Journal
