摘要
目的:观察督灸治疗慢性乙型肝炎的临床疗效。方法:将60例脾肾阳虚的慢性乙型肝炎患者随机分为督灸联合干扰素组(治疗组)和干扰素组(对照组),每组各30例,观察治疗12周、24周、48周患者的肝功能(ALT)、HBV-DNA阴转情况、HBe Ag血清学转换情况、外周血中性粒细胞计数变化情况以及中医症候变化情况。结果:两组患者在治疗12周、24周、48周时ALT与治疗前相比均有显著性差异(P<0.05);治疗12周、24周时两组间ALT比较有显著性差异(P<0.05),治疗组优于对照组,治疗48周时比较无显著性差异(P>0.05)。两组患者HBV-DNA阴转率、血清学HBe Ag转换率以及外周血中性粒细胞计数在治疗12周时,组间比较均无显著性差异(P>0.05);治疗24周、48周时,组间比较均有显著性差异(P<0.05),治疗组优于对照组。治疗组对中医症候的改善情况优于对照组,差异有显著性(P<0.05)。结论:督灸联合干扰素治疗慢性乙型肝炎的临床疗效优于单纯应用干扰素治疗,这对进一步研究督灸治疗慢性乙型肝炎的减毒、增效作用及推广应用有重要意义。
Objective： To observe the clinical effect of Du-moxibustion on chronic hepatitis B. Methods： 60 cases of chronic hepatitis B with yang deficiency of Kidney and Spleen were randomly divided into the observation group（ Du-moxibustion ＋ interferon,n = 30） and the control group（ interferon,n = 30）. ALT value,negative conversion ratio of HBV-DNA,HBe Ag seroconversion,neutrophil count of peripheral blood,and the changes of TCM symptoms were observed after 12 w,24 w,and 48 w of treatment. Results： In terms of ALT value,it was significantly decreased after 12 w,24 w,and 48 w of treatment in the two groups,compared to that before the treatment（ P〈0. 05）; it decreased more after 12 w and 24 w of treatment in the observation group than that of the control group（ P〈0. 05）; no difference was seen after 48 w of treatment between the two groups（ P〉0. 05）. In terms of negative conversion ratio of HBV-DNA,HBe Ag seroconversion,and neutrophil count of peripheral blood,there were no significant differences between the two groups after 12 w of treatment（ P〉0. 05）; there were significant differences between the two groups after 24 w and 48 w of treatment（ P〈0. 05）,the improvement in the observation group was more significant than that in the control group. TCM symptoms were relieved more in the observation group than that in the control group（ P〈0. 05）. Conclusion：The therapy of Du-moxibustion combined with interferon is superior to single interferon in treatment of chronic hepatitis B. This is of great significance for further research on attenuation and synergia of Du-moxibustion.
作者
任萃萃
朱维平
REN Cuicui;ZHU Weiping(Qingdao No.6 People＇s Hospital,Qingdao 266033,China;Qingdao Haici Medical Group,Qingdao 266033,China)
出处
《针灸临床杂志》
2018年第6期1-4,共4页
Journal of Clinical Acupuncture and Moxibustion
基金
山东省中医药管理局科技发展计划项目
编号:2015-371
关键词
督灸
干扰素
慢性乙型肝炎
Du - moxibustion
Interferon
Chronic hepatitis B
