摘要
目的探讨强直性脊柱炎(Ankylosing spondylitis,AS)患者近期感染与其疾病活动的相关性。方法选取2013-03-2016-06门诊收治的70例AS患者作为AS组,选择同期来医院体检的40例健康正常人作为对照组,测定两组外周血肺炎衣原体(Cpn)特异性抗体免疫球蛋白A(Ig A)、免疫球蛋白M(Ig M)、免疫球蛋白G(Ig G),并比较Cpn特异性抗体阳性与阴性AS患者疾病活动指数(BASDAI)、实验室指标等指标的差异,分析AS近期感染与疾病活动度的关系。结果(1)AS组与对照组Cpn-Ig G及总抗体阳性率均处于较高水平,但AS组Cpn-Ig M、Cpn-Ig M或Cpn-Ig A阳性率明显高于对照组(P<0.05)。(2)Ig M阳性患者ESR、CRP、WBC、BASDAI均高于阴性者(P<0.05)。(3)Ig M、Ig A均与AS患者BASDAI呈正相关,其中Ig M呈高度相关(P<0.05)。(4)持续Cpn-Ig M阳性患者BASDAI明显高于转阴患者(P<0.05)。结论 Cpn近期感染是AS发病的重要诱因,且与患者病情进展有关,而予积极的抗感染治疗则为降低AS患者疾病活动度的重要途径。
Objective To investigate the correlation between recent infection and disease activity in patients with ankylosing spondylitis（AS）. Methods From March 2013 to June 2016, a total of 70 patients with AS treated in our hospital were selected as AS group, and at the same time, 40 healthy people were selected as control group. The specific antibodies of chlamydia pneumoniae（Cpn）,immunoglobulin A（Ig A）, immunoglobulin M（Ig M） and immunoglobulin G（Ig G） in peripheral blood of two groups were determined. The bath AS disease activity index（BASDAI） and laboratory indicators were compared between patients with Cpn positive and negative AS, and the relationship between recent infection and disease activity in patients with AS was analyzed. Results（1）Cpn-Ig G and total antibody positive rates were relatively higher in the two groups, but the positive rates of Cpn-Ig M,Cpn-Ig M or Cpn-Ig A in AS group were significantly higher than those in control group（P0.05）.（2）The ESR, CRP, WBC and BASDAI in Ig M positive patients were higher than those in Ig M negative patients（P0.05）.（3）Ig M and Ig A were positively correlated with BASDAI in patients with AS, and Ig M was highly correlated with BASDAI（P0.05）.（4）BASDAI of continuously Cpn-Ig M positive patients was significantly higher than that of negative conversion patients（P〈0.05）. Conclusion Cpn recent infection is an important cause of AS, and it is related to the progression of the patients＇ condition.Active anti-infection therapy is an important way to reduce the activity of AS in patients.
作者
吴海龙
张帅
张斌
张立兴
WU Hai-long;ZHANG Shuai;ZHANG Bin;ZHANG Li-xing(the Second Department of Orthopedics,the First Hospital of Shijiazhuang,Shijiazhuang Hebei,050000,China)
出处
《颈腰痛杂志》
2018年第3期293-296,共4页
The Journal of Cervicodynia and Lumbodynia
关键词
强直性脊柱炎
肺炎支原体感染
疾病活动度
ankylosing spondylitis
myeoplasma pneumoniae inteetion
disease activity
