摘要
目的:分析我院注射用丹参多酚酸盐的用药情况及所致不良反应/事件(ADR/ADE)发生的规律、特点,为临床合理用药提供参考。方法:采用回顾性研究方法,利用我院HIS系统,调取我院2016年1月–2017年8月使用该药的病例,共计8008例,从适应证、疗程、给药剂量、溶媒和溶媒量、联合或交替用药、冲管、滴速等方面,以及上报国家药品不良反应监测中心的21例发生ADR/ADE的病例进行统计分析。结果:8008例使用注射用丹参多酚酸盐的病例中,适应证不适宜4796例(59.89%)、给药剂量不适宜56例(0.70%)、溶媒和溶媒量不适宜1433例(17.89%)、联合或交替用药1602例(20.00%)、疗程不适宜7242例(90.43%)、未冲管3332例(41.61%)。发生的21例ADR/ADE中,无适应证2例(9.52%),溶媒量不适宜4例(19.05%),未冲管18例(85.71%),滴速不适宜21例(100.00%)。结论:不合理用药是ADR/ADE发生的主要原因之一,应严格按药品说明书规定使用注射用丹参多酚酸盐。
Objective： To analyze the utilization of salvianolate injection in our hospital and the regularity and characteristics of ADR/ADE associated with salvianolate injection, in order to provide references for clinical rational drug use.Methods： A retrospective study was conducted on 8008 cases using salvianolate injection from January 2016 to August 2017. The indication, duration of treatment, dosage, solvent, amount of solvent, drug combination, flushing tubes, drop rate and 21 ADRs/ADEs associated with salvianolate injection from the national adverse drug reaction monitoring center were analyzed. Results： Among the 8008 cases, there were 4796 cases（59.89%） without indications, 56 cases（0.70%） with inappropriate dosage, 1433 cases（17.89%） with inappropriate solvent and solvent volume, 1602 cases（20.00%） with combination or alternate use, 7242 cases（90.43%） with inappropriate duration, 3332 cases（41.61%） without flushing tubes. Among the 21 ADR/ADE cases, there were 2 cases（9.52%） without indications, 4 cases（19.05%） with unsuitable amount of solvent, 18 cases（85.71%） without flushing tubes and 21 cases（100.00%） with inappropriate drop rate. Conclusion： Irrational drug use is one of the main reasons for ADR/ADE, salvianolate injection should be used in strict accordance with the drug instructions.
作者
毕铁琳
于倩
谢程
BI Tie-lin;YU Qian;XIE Cheng(Department of Pharmacy,China-Japan Union Hospital of Jilin University,Changchun 130033,China)
出处
《中国药物应用与监测》
CAS
2018年第3期165-168,共4页
Chinese Journal of Drug Application and Monitoring
基金
吉林省食品药品安全监测中心科技项目(2015474)
