摘要
目的分析珂立苏联合西地那非治疗新生儿持续肺动脉高压的效果。方法选择2011年4月至2016年2月临夏回族自治州人民医院收治住院的新生儿持续肺动脉高压患儿200例为研究对象,其中2011年4月至2014年4月收治的100例为对照组,2014年5月至2016年2月收治的100例患儿为观察组。两组同时积极治疗原发病、机械通气支持,对照组给予20%硫酸镁静脉滴注,观察组在对照组治疗基础上给予西地那非联合珂立苏治疗,连续治疗3d。观察两组临床疗效、多普勒超声测量肺动脉压力及相关实验室指标检测。结果观察组总有效率为95.0%(95/100),显著高于对照组65.0%(65/100),差异有统计学意义(P<0.05)。治疗后观察组肺动脉压力显著低于对照组,差异有统计学意义(P<0.05)。观察组用药后的相关血气分析指标均明显优于对照组,差异有统计学意义(P<0.05)。结论珂立苏联合西地那非治疗新生儿持续肺动脉高压,可明确改善患儿临床症状,血气相关指标及多普勒超声心动图下肺动脉压力下降,促进病情恢复。
Objective To analyze the effect of sildenafil combined with Calsurf in the treatment of neonatal with persistent pulmonary hypertension.Methods A total of 200 PPHN neonates were selected as the research subjects,who were treated in Linxia State People＇s Hospital from April 2011 to February 2016;the 100 neonates treated from April 2011 to April 2014 were in the control group,while the 100 from May 2011 to February 2016 were included in the observation group.Both groups received positive treatment for primary diseases and support of mechanical ventilation,and intravenous dripping of 20% magnesium sulfate;in addition,the observation group was treated by sildenafil combined with Calsurf.The treatment lasted for 3 days;observe the clinical effect,measure the pulmonary pressure by Doppler ultrasound,and detect the related laboratory indexes in the two groups.Results The total effective rate of observation group was 95.0%（95/100）,significantly higher than that of control group（65.0%,65/100）.The pulmonary pressure after treatment was significantly lower in the observation group,and there was statistical difference（P〈0.05）.The related blood gas indexes after treatment in the observation group were significantly better than those in the control group（P〈0.05）.Conclusion Calsurf combined with sildenafil for neonates with persistent pulmonary hypertension can obviously improve the clinical symptoms of the neonates;after treatment,the blood-gas-related indexes are decreased,and the Doppler ultrasonography shows a decrease in pulmonary pressure,which promotes the improvement of the disease.
作者
崔培聪
胡宜莲
张绍鹏
CUI Peicong;HU Yilian;ZHANG Shaopeng(Linxia State People＇s Hospital,Linxia 731100,China)
出处
《中国中西医结合儿科学》
2018年第3期245-248,共4页
Chinese Pediatrics of Integrated Traditional and Western Medicine
关键词
新生儿持续肺动脉高压
珂立苏
西地那非
硫酸镁
机械通气
Neonatal persistent pulmonary hypertension
Calsurf sildenafil
Magnesium sulfate
Mechanical ventilation
