摘要
地高辛广泛应用于心源性疾病,但往往难以掌握确切剂量。本研究的目的为分析患者生理因素及肝肾功能相关指标对地高辛血药浓度水平的影响,为合理地应用地高辛提供理论参考。回顾性收集南京鼓楼医院2016~2017年口服应用地高辛的住院患者病历资料,聚焦肝肾功能相关指标,利用描述性统计方法对患者综合情况进行分析。按照纳入标准,共计收集256例应用地高辛的患者。相关性分析显示:患者体重、血糖、舒张压、尿素、肌酐、肾小球滤过率共计6项因素与地高辛的血药浓度值显著相关(P<0.05)。考察结果,患者的体重、血糖、舒张压、尿素、肾小球滤过率纳入了地高辛血药浓度的回归模型,且此回归模型用于地高辛血药浓度的预测具有临床意义。
Digoxin is widely used in cardiogenic diseases, but it is often difficult to grasp the exact dose. The objectives of this study were to investigate the effects of physiological factors and liver and kidney function related indexes on the serum concentration of digoxin, and aimed to provide theoretical reference for the rational use of digoxin. We collected data of 256 hospitalized patients who accepted oral digoxin for treatment in Nanjing Drum Tower Hospital from 2016 to 2017. Descriptive statistics were used to analyze the patients＇ comprehensive situation focusing on liver and kidney function indexes. Correlation analysis showed that 6 factors including body weight, blood glucose, diastolic blood pressure, urea, creatinine and glomerular filtration rate were significantly correlated with the serum concentration of digoxin（P0.05）. Finally, body weight, blood glucose, diastolic blood pressure, urea and glomerular filtration rate were included in the regression model of digoxin serum concentration, and the regression model for the prediction of digoxin serum concentration has clinical significance.
作者
沈纪中
朱怀军
柳航
罗雪梅
金路
李丹滢
张海霞
葛卫红
SHEN Jizhong;ZHU Huaijun;LIU Hang;LUO Xuemei;JIN Lu;LI Danying;ZHANG Haixia;GE Weihong(Department of Pharmacy,Drum Tower Hospital Affiliated to Medical School of Nanjing University,Nanjing 210008,China)
出处
《药学与临床研究》
2018年第3期183-186,共4页
Pharmaceutical and Clinical Research
基金
国家自然科学基金项目(81302817)
江苏省六大人才高峰计划项目(WSN-004)
南京药学会常州四药科研项目(2013YX006)
中央高校基本科研业务费项目(021414340276/021414380198)
江苏省医学创新团队项目(CXTDA2017041)
关键词
地高辛
治疗药物监测
肝功能
肾功能
个体化给药
Digoxin
Therapeutic drug monitoring
Liver function
Renal function
Individualized medication
