摘要
目的探讨动脉溶栓治疗老年急性脑梗死的临床效果和安全性。方法选取2014年6月至2016年12月本院收治的72例急性脑梗死患者为研究对象,采用随机数表法将其分为观察组(38例)和对照组(34例),观察组患者采取动脉溶栓治疗,对照组患者采取静脉溶栓治疗。比较两组患者的临床治疗效果、神经功能、生存质量及不良反应发生情况。结果治疗7天后,两组患者美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分均显著低于治疗前(P<0.05),且观察组患者NIHSS评分显著低于对照组(P<0.05)。观察组患者治疗总有效率显著高于对照组(P<0.05);治疗28天后,两组患者Bathel指数评分均显著高于治疗前(P<0.05),且观察组患者Bathel指数评分显著高于对照组(P<0.05);观察组患者颅内出血、再灌注损伤、血管再闭塞的发生率均显著低于对照组(P<0.05)。结论动脉溶栓治疗老年急性脑梗死具有起效快、效果好、安全性高的优势,同时能提高患者生活自理能力和生活质量,在条件允许的情况下,可选用该治疗方案。
Objective To explore the clinical effects and safety of arterial thrombolytic therapy in elderly patients with acute cerebral infarction. Method From June 2014 to December 2016, 72 patients with acute cerebral infarction in our hospital were selected as the research objects, they were randomly divided into observation group（38 cases） and control group（34 cases）, patients in observation group were treated with arterial thrombolysis, while patients in control group were treated with intravenous thrombolysis, clinical effect, life quality and adverse reactions were compared between the two groups. Result 7 days after treatment, National Institutes of Health Stroke Scale（NIHSS） score of the two groups were lower than that before treatment（P〈0.05）, and NIHSS score of observation group was lower than that of control group（P〈0.05）; the total efficiency of observation group was higher than that of control group（P〈0.05）; 28 days after treatment, the Bathel index of the two groups were higher than that before treatment（P〈0.05）, and Bathel index of observation group was higher than that of control group（P〈0.05）; the incidence rate of intracranial hemorrhage reperfusion injury and vascular occlusion of observation group were lower than those of control group（P〈0.05）. Conclusion Arterial thrombolytic therapy has the advantages of quick onset, good clinical effect and high safety in the treatment of elderly patients with acute cerebral infarction. Meanwhile, it can improve the self-care ability and quality of life of patients.
作者
李琳
蒋智林
LI Lin;JIANG Zhi-lin(Department of Neurology, 202 Hospital of PLA, Shenyang 110003, China)
出处
《中国医学前沿杂志（电子版）》
2018年第4期15-18,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
基金
辽宁省自然科学基金指导计划(20170540913)
关键词
急性脑梗死
溶栓治疗
老年
Acute cerebral infarction
Thrombolytic therapy
Elderly
