摘要
目的:探讨超声介入治疗联合化疗在中央型肺癌伴脑转移患者治疗中对肿瘤标志物和生存期的影响。方法:选取中央型肺癌伴脑转移的患者82例,根据数字表法随机分为观察组(42例)和对照组(40例)。对照组采用吉西他滨联合顺铂方案静脉化疗,观察组在对照组的基础上采用超声介入治疗。对两组患者的近期疗效和治疗前后肿瘤标志物及血管内皮生长因子进行评估,并通过门诊或电话随访两年。结果:观察组的治疗有效率和控制率分别为45.2%和85.7%,对照组为30.0%和70.0%,观察组的近期疗效显著优于对照组(P<0.05);治疗前,两组患者的肿瘤标志物(CEA、CA125、CA19-9、SCCAg、NSE)和血管内皮生长因子(VEGFA、VEGFB、VEGFC)水平无显著差异,治疗后,其在两组患者中的表达量均下降,观察组的改善程度显著高于对照组(P<0.05)。随访两年结果显示,观察组患者的中位无进展生存期为5个月,中位总生存期为8个月,对照组分别为3个月和5个月。观察组的6个月和12个月生存率分别为67.3%和26.9%,而对照组则分别为28.9%和15.7%。两组患者两年随访结果有统计学意义(P<0.05)。结论:超声介入治疗联合化疗在中央型肺癌伴脑转移患者的治疗中,可以显著降低肿瘤标志物的表达水平,延长生存时间。
Objective：To investigate the effect of ultrasound interventional therapy combined with chemotherapy on tumor markers and survival time in patients with central lung cancer complicated with brain metastasis. Methods：82 patients with central lung cancer were selected. They were randomly divided into the observation group（42 cases） and the control group（40 cases）. The control group received gemcitabine combined with cisplatin intravenous chemotherapy,and the observation group was treated with interventional ultrasound on the basis of the control group. The short-term efficacy,tumor markers and vascular endothelial growth factor were evaluated before and after treatment. The patients were followed up for 2 years by clinic service or telephone. Results：The effective rate and the control rate in the observation group were 45. 2% and 85. 7%,respectively. While in the control group the effective rate and the control rate was 30. 0% and 70. 0%,respectively. The results of the observation group were significantly better than that in the control group（ P〈0. 05）. Tumor markers（ CEA,CA125,CA19-9,SCC-Ag,NSE） and vascular endothelial growth（ VEGFA,VEGFB,VEGFC factor） level had no significant difference between the two groups before treatment（ P〉0. 05）. After treatment,the expression of tumor markers in the two groups were decreased,but the improvement degree in the observation group was significantly higher than that in the control group（ P〈0. 05）. Followed up for 2 years,the median PFS and the median OS in the observation group were 5 months and 8 months,respectively. But in the control group,they were 3 months and 5 months,respectively. In addition,the 6 months and 12 months survival rate in the observe group were 67. 3% and 26. 9%,respectively,while in the control group they were 28. 9% and 15. 7%.There were statistical significance different in two groups by followed up for two years（ P〈0. 05）. Conclusion：Ultrasound interventional therapy combined with chemotherapy for the tre
作者
任辉
申纪锐
REN Hui;SHEN Ji-rui(Department of Ultrasound,the Third People＇ s Hospital of Liaocheng,Liaocheng 252000,Shandong,China)
出处
《川北医学院学报》
CAS
2018年第3期435-438,共4页
Journal of North Sichuan Medical College
关键词
超声介入治疗
中央型肺癌
脑转移瘤
肿瘤标志物
生存期
Ultrasound interventional treatment
Central lung cancer
Brain metastasis
Tumor markers
Survival period
