摘要
目的探讨归芍左归饮治疗肝肾阴虚型外阴营养不良的效果及对免疫功能的影响。方法选择2014年1月~2017年1月成都中医药大学附属医院收治的104例肝肾阴虚型外阴营养不良患者,按随机数字表法将其随机分为对照组和治疗组,每组各52例。对照组患者给予常规治疗,治疗组在对照组治疗的基础上联合给予归芍左归饮,两组均连续治疗1个月。治疗后进行临床疗效评价。评价并比较两组治疗前后的中医证候评分和外阴皮肤色素减退积分。检测并比较两组治疗前后外周血CD3^+、CD4^+、CD8^+细胞所占比值及CD4^+/CD8^+。记录并比较两组治疗过程中不良反应的发生情况。结果治疗组总有效率为96.15%(50/52),对照组为69.23%(36/52),差异有高度统计学意义(χ~2=13.168,P<0.01)。治疗后,治疗组中医证候积分、外阴皮肤色素减退积分,以及外周血CD3^+、CD4^+细胞所占比值及CD4^+/CD8^+均小于对照组(P<0.01),外周血CD8^+细胞所占比值大于对照组(P<0.01)。两组治疗过程中均无严重不良反应发生。结论归芍左归饮治疗肝肾阴虚型外阴营养不良临床效果显著,能够明显减轻临床症状,改善患者细胞免疫功能,且安全性较好,值得在临床上推广应用。
Objective To explore clinical effects of Guishao Zuogui Yin in treating vulvar dystrophy with syndrome of yin deficiency of liver and kidney and the influence on immune function.Methods According to the random number table,104 cases of patients with vulvar dystrophy with syndrome of yin deficiency of liver and kidney admitted to Affiliated Hospital of Chengdu University of Traditional Chinese Medicine from January 2014 to January 2017 were selected,and they were divided into treatment group and control group,with 52 cases in each group.The control group was treated with conventional treatment,while the treatment group was treated with conventional medicine combined with Guishao Zuogui Yin.The two groups were treated for 1 month.The clinical curative effect was evaluated after treatment.The TCM symptom scores,vulvar skin pigment loss scores,CD3~＋,CD4~＋,CD8~＋and CD4~＋/CD8~＋of the two groups were compared before and after treatment.The adverse reactions of the two groups during the treatment were recorded and compared.Results The total effective rate of observation group was 96.15%（50/52）,which of control group was 69.23%（36/52）,the difference was statistically significant（χ~2=13.168,P〈0.01）.After treatment,the TCM symptom scores,vulvar skin pigment loss scores,CD3~＋,CD4~＋and CD4~＋/CD8~＋of the treatment group were lower than those of the control group（P〈0.01）,the CD8~＋of the treatment group was higher than that of the control group（P〈0.01）.There were no serious adverse reactions of the two groups during treatment.Conclusion Guishao Zuogui Yin in the treatment of vulvar dystrophy with syndrome of yin deficiency of liver and kidney has a good efficacy and few adverse reactions,which can reduce the clinical symptoms,improve the immune function,and it is worthy of clinical promotion and application.
作者
刘艺
邓琳雯
LIU Yi;DENG Linwen(Department of Gynaecology,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,SichuanProvince,Chengdu 610075,China)
出处
《中国医药导报》
CAS
2018年第16期101-104,共4页
China Medical Herald
基金
四川省中医药管理局科研项目(2014-A-005)
关键词
外阴营养不良
肝肾阴虚
归芍左归饮
疗效
免疫功能
Vulvar dystrophy
Yin deficiency of liverand kidney
Guishao Zuogui Yin
Efficacy
Immunefunction
