摘要
目的:观察桑叶提取物联合有氧运动治疗肥胖型2型糖尿病的临床疗效,并分析其作用机制。方法:184例肥胖型2型糖尿病患者随机分为对照组和观察组。对照组给予利拉鲁肽联合胰岛素;观察组给予桑叶提取物联合有氧运动。比较治疗前后两组患者腰围、体质量、糖化血红蛋白(hemoglobin Alc,Hb A1c)、餐后2小时血糖(2-hour post-meal blood glucose,2h PG)、空腹血糖(fasting blood-glucose,FBG)、三酰甘油(triacylglycerol,TG)、总胆固醇(total cholesterol,TC)、中医证候积分、生存质量积分的变化情况及不良反应发生情况,并比较两组患者临床疗效。结果:观察组有效率为94.56%,对照组为82.61%,两组比较,差异有统计学意义(P<0.05)。治疗后,两组腰围、体质量、Hb A1c、2h PG、FBG、TG、TC、中医证候积分较治疗前均明显降低,而生存质量积分均明显增高,且观察组上述观察指标均明显优于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率为1.09%,对照组为3.26%,两组比较,差异无统计学意义(P>0.05)。结论:采用桑叶提取物联合有氧运动治疗肥胖型2型糖尿病,可显著提高临床疗效,降低血脂、血糖水平,缓解临床症状,促进患者身体恢复,提高生存质量。
Objective：To observe the clinical efficacy of Mulberry leaf extract combined with aerobic exercise in treatment of type 2 diabetes due to obesity and analyze its mechanism of action. Methods：184 patients with type 2 diabetes with obesity were randomly divided into control group and observation group. The control group received liraglutide combined with insulin; the observation group received Mulberry leaf extract combined with aerobic exercise. The waist circumference,body weight,hemoglobin Alc（Hb A1 c）,2-hour post-meal blood glucose（2 h PG）,fasting blood-glucose（FBG）,three groups were compared before and after treatment. The changes of triacylglycerol（ TG）,total cholesterol（ TC）,TCM syndrome scores,quality of life scores,and occurrence of adverse reactions were compared. Clinical efficacy of the two groups was compared. Results： The effective rate was94. 56% in the observation group and 82. 61% in the control group. There was a significant difference between the two groups（P〈0. 05）. After treatment,the waist circumference,body weight,Hb A1 c,2 h PG,FPG,TG,TC,and TCM syndrome scores of both groups were significantly lower than before treatment,and the quality of life scores were significantly higher,and the observation indexes in the observation group were significantly better than that of the control group,the differences were statistically significant（P〈0. 05）. The incidence of adverse reactions was 1. 09% in the observation group and 3. 26% in the control group. There was no significant difference between the two groups（ P〈0. 05）. Conclusion：The use of Mulberry extract combined with aerobic exercise to treat type 2 diabetes due to obesity can significantly improve the efficacy,reduce blood lipids and blood glucose levels,relieve clinical symptoms,promote physical recovery and improve patients＇ quality of life.
作者
齐刚
王继锋
齐凤军
王金枝
朱丹
QI Gang;WANG Jifeng;QI Fengjun;WANG Jinzhi;ZHU Dan(Xiangyang Hospital Affiliated to Hubei University of Medicine,Xiangyang Hubei China 441000;Hubei University of Chinese Medicine,Wuhan Hubei China 430065)
出处
《中医学报》
CAS
2018年第7期1230-1235,共6页
Acta Chinese Medicine
基金
湖北省自然科学基金重点项目(2014CFA085)
湖北省医学领军人才培养工程专项经费资助项目{鄂卫生计生发[2013]4号}
关键词
肥胖型2型糖尿病
桑叶提取物
有氧运动
利拉鲁肽
胰岛素
血糖
血脂
中医证候积分
中西医结合
type 2 diabetes due to Obesity
Mulberry extract
aerobic exercise
Liraglutide
Insulin
blood glucose
blood lipids
syndrome scores of traditional Chinese medicine
Integrative medicine
