摘要
目的:观察柴胡桂枝干姜汤治疗肺结核的临床疗效。方法:140例肺结核患者按照随机数字表法平均分为对照组与观察组。对照组患者给予2HRZE/4HR方案化疗,观察组患者在对照组治疗基础上给予柴胡桂枝干姜汤。比较两组患者治疗前后生存质量、临床症状、痰菌阴转率、不良反应发生情况,并比较两组患者临床疗效。结果:观察组有效率为91.43%(64/70),明显高于对照组的78.57%(55/70);与治疗前比较,治疗后两组患者中医证候积分均明显下降,而生存质量评分均明显上升,且观察组生存质量评分更高,而中医证候积分更低,差异有统计学意义(P<0.05);治疗后4周、8周、12周、24周观察组痰菌阴转率均高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为8.57%,对照组为5.71%,两组比较,差异无统计学意义(P>0.05)。结论:柴胡桂枝干姜汤治疗肺结核疗效显著,可缓解临床症状,提高痰菌阴转率和生存质量,且不会增加不良反应发生率。
Objective：To observe the clinical curative effect of Chaihu Guizhi Ganjiang Decoction in treating for pulmonary tuberculosis. Methods：A total of 140 patients with pulmonary tuberculosis were randomly divided into control group and observation group.The patients in the control group were given 2 HRZE/4 HR regimen chemotherapy,and the observation group patients were given Chaihu Guizhi Ganjiang Decoction in addition to that of the control group. The quality of life,clinical symptoms,sputum negative transformation and adverse reactions before and after treatment were compared between the two groups of patients,and the clinical efficacy of the two groups was compared. Results：The effective rate in the observation group was 91. 43%（64/70）,which was significantly higher than that（78. 57%,55/70） in the control group. Compared with that before treatment,the scores of TCM syndromes of both groups decreased significantly after treatment,and the quality of patients＇ life was improved. The scores increased significantly,and the quality of life scores in the observation group were higher,but the scores of TCM syndromes were lower,the difference was statistically significant（ P〈0. 05）. The observation group was observed at 4 weeks,8 weeks,12 weeks,and 24 weeks after treatment. The negative conversion rate was higher than that of the control group,and the difference was statistically significant（ P〈0. 05）. The incidence of adverse reactions in the observation group was 8. 57%,and that of the control group was5. 71%. There was no significant difference between the two groups（ P〈0. 05）. Conclusion：Chaihu Guizhi Ganjiang Decoction is effective in treatment of pulmonary tuberculosis,which can relieve clinical symptoms,increase the rate of sputum negative conversion and improve patients＇ quality of life,yet does not increase the incidence of adverse reactions.
作者
苏汝开
王景科
邓伦杰
SU Rukai;WANG Jingke;DENG Lunjie(The People＇s Hospital of Haikou City,Haikou Hainan China 57020)
出处
《中医学报》
CAS
2018年第7期1208-1212,共5页
Acta Chinese Medicine
基金
海南省自然科学基金资助项目(2013-813172)
关键词
柴胡桂枝干姜汤
肺结核
生存质量
痰菌阴转
中西医结合
Chaihu Guizhi Ganjiang Decoction
pulmonary tuberculosis
quality of life
sputum negative transformation
Integrativemedicine
