摘要
目的:观察二母散对肺阴亏虚型老年慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)稳定期患者肺功能的影响。方法:188例肺阴亏虚型老年COPD稳定期患者按随机数字表法平均分为对照组和观察组。对照组给予舒利迭50/250治疗,观察组给予二母散治疗,均治疗3个疗程。比较两组患者治疗前后肺功能:第1秒用力呼气容积(forced expiratory volume in one second,FEV1),FEV1/用力肺活量(forced vital capacity,FEV1/FVC);中医证候积分;痰液中炎症指标:肿瘤坏死因子-α(tumor necrosis factor,TNF-α),白细胞介素-8(interleukin-8,IL-8);生存质量评分及不良反应;并比较两组患者临床疗效。结果:治疗后,观察组FEV1、FEV1/FVC与对照组比较,差异无统计学意义(P>0.05);观察组生存质量评分明显高于对照组,痰液中TNF-α、IL-8、中医证候积分均明显低于对照组,差异均有统计学意义(P<0.05);观察组有效率为94.68%,对照组为80.85%,两组比较,差异有统计学意义(P<0.05);观察组不良反应发生率为1.06%,对照组为8.51%,两组比较,差异有统计学意义(P<0.05)。结论:二母散治疗稳定期肺阴亏虚型老年COPD患者临床疗效显著,可显著改善患者肺功能,降低炎症指标水平,缓解临床症状,且不良反应发生率较低。
Objective：To observe the effect of Er Mu Powder on the lung function of chronic obstructive pulmonary disease（ COPD）in elderly patients in stable phase with Lung Yin Deficiency Syndrome. Methods：188 patients were divided into control group and observation group according to the random number table method. The control group was given 50/250 treatment with Seretide,and the observation group was given Er Mu Powder in treatment. The treatment treated for 3 courses. Pulmonary function before and after treatment was compared between the two groups：Forced expiratory volume in one second（ FEV1）,FEV1/FVC/FEV1/FVC;TCM syndrome score; inflammation in sputum Indices： tumor necrosis factor-α（ TNF-α）,interleukin-8（ IL-8）; quality of life scores and adverse reactions;and clinical efficacy of the two groups were compared. Results：After treatment,there was no significant difference in FEV1,FEV1/FVC between the observation group and the control group（ P〈0. 05）. The quality of life score in the observation group was significantly higher than that in the control group,and sputum TNF-α,IL-8,The scores of TCM syndromes were significantly lower than those of the control group（ P〈0. 05）. The effective rate was 94. 68% in the observation group and 80. 85% in the control group. There was a statistically significant difference between the two groups（ P〈0. 05）. The occurrence of the adverse reactions was 1. 06% in the observation group and 8. 51% in the control group. There was a significant difference between the two groups（ P〈0. 05）. Conclusion：Er Mu Powder in treatment of chronic obstructive pulmonary disease（COPD） in elderly patients in stable phase is effective,which can significantly improve lung function,reduce the level of inflammation,relieve clinical symptoms,and have a lower incidence of adverse reactions.
作者
渠乐
周云
QU Le;ZHOU Yun(The TCM Hospital of Uygur Autonomous Region of Xinjiang,Urumqi Xinjiang China 830000;Chinese Medicine Hospital Affiliated to Xinjiang Medical University,Urumqi Xinjiang China 830000)
出处
《中医学报》
CAS
2018年第7期1197-1202,共6页
Acta Chinese Medicine
基金
新疆维吾尔自治区自然科学基金项目(20142-11C098)
关键词
慢性阻塞性肺疾病
肺阴亏虚证
二母散
肺功能
肿瘤坏死因子-Α
白细胞介素-8
中医药治疗
chronic obstructive pulmonary disease
Lung Yin Deficiency Syndrome
Er Mu Powder
pulmonary function
tumor nec-rosis factor-α
interleukin-8
Chinese medicine treatment
