摘要
Objective： The objective of this study is to evaluate the impact of various traditional Chinese medicine （TCM）approaches on the quality of life in patients with colorectal cancer. Methods： In this study, we systematically performedthe screening of randomized controlled trials from Cochrane Library, Pubmed, Embase, Medline, and Web of Science.The data were extracted by two reviewers independently, and then risk assessment was performed. All the analyses wereconducted using Review Manager 5.3. Results： A total of 18 eligible studies containing 1312 patients were included.Experimental group were treated with TCM combined with Western medicine or TCM alone （N = 688） and controlgroup were treated with Western medicine treatment alone （N = 624）. The results showed that the recent clinicalefficiency between the two groups was not statistically significant （P = 0.06）. KPS scores of the experimental group werehigher than those in the control group [P 〈 0.001, WMD = 9.60, 95%CI = （5.62, 13.57）]. The toxicity comparisonshowed that the occurrence of toxicities, such as leucopenia, thrombocytopenia, nausea and vomiting, diarrhea, andneurotoxicity in the experimental group was lower than that in the control group [P 〈 0.001, OR = 0.31, 95%CI = （0.19,0.50）], [P = 0.003, OR = 0.49, 95%CI = （0.31, 0.78）], [P 〈 0.001, OR = 0.30, 95%CI = （0.16, 0.54）], [P 〈 0.001, OR =0.40, 95%CI = （0.27, 0.58）], and [P 〈 0.001, OR = 0.43, 95%CI = （0.30, 0.61）]. The immunological test comparisondemonstrated that the immunological parameters （CD3, CD4, and CD4/CD8） showed higher values in the experimentalgroup than those in the control group [P 〈 0.001, MD = 5.55, 95%CI = （4.83, 6.28）], [P 〈 0.0001, MD = 6.75, 95%CI =（5.25, 8.26）], and [P = 0.001, MD = 0.26, 95%CI = （0.10, 0.41）]. Conclusions： TCM did not show significant recentclinical efficiency. However, treatment with TCM showed increase in KPS scores in patients with colorectal cancer,alleviation of toxicity associate
目的：评价不同中医药方法对结直肠癌患者生活质量的影响.方法：从Cochrane,Pubmed,Embase,Medline和Web of Science数据库中筛选随机对照试验来进行系统研究,并由两名评审员独立提取数据,使用软件ReviewManager5.3进行数据处理.结果：共有18个合格研究,1312名患者被纳入.实验组采用中医药结合西医治疗,或单纯中医药治疗;对照组采用西医治疗.结果显示：（1）实验组与对照组近期有效率比较,差异不具有统计学意义【P=0.06,0R=1.38,95%CI=（0.98,1.95）】.（2）实验组的KPS评分高于对照组【P〈0.001,WMD=9.60,95%CI=（5.62,13.57）】.（3）实验组与对照组毒副反应比较：实验组白细胞下降,血小板减少,恶心呕吐,腹泻,神经毒性不良反应的发生率均低于对照组【P〈0.001,OR=0.31,95%CI=（0.19,0.50）】,【P=0.003,OR=0.49,95%CI=（0.31,0.78）】,【P〈0.001,OR=0.30,95%CI=（0.16,0.54）】,【P〈0.001,OR=0.40,95%CI=（0.27,0.58）】和【P〈0.001,OR=0.43,95%CI=（0.30,0.61）】.（4）实验组与对照组免疫学检测比较：实验组的CD3,CD4,和CD4/CD8的均值均高于对照组【P〈0.001,MD=5.55,95%CI=（4.83,6.28）】,[P〈0.001,MD=6.75,95%CI=（5.25,8.26）】,[P=0.001,MD=0.26,95%CI=（0.10,0.41）】.结论：中医药对结直肠癌患者的近期临床有效率作用不显著,但可提高患者的KPS评分,缓解化疗的毒副作用,调节自身免疫,改善患者的生活质量.
基金
National Natural Science Foundation of China （81460697, 81460691, 81673862）. Project of Science andTechnology Department of Guizhou Province. SY Word of Science and Technology Cooperation of Qian （2013, 3026
2014, 3008-1
2014, 3026
2015, 3028）. Talents of Science and Technology Cooperation of Qian （2016, 4032）.
