摘要
Pancreatic cancer is among the most lethal malignancies resistant to conventional therapies. The urgent need fornew therapies has turned the spotlights on immunotherapy. In recent years, a growing body of evidence has alreadybeen gathered regarding the efficacy of genetic engineering modified T-cells, checkpoint inhibitors of T-cells, killercells induced by dendritic cells and cytokine in patients with pancreatic cancer. Cryoimmunotherapy in situ andextra-tumor and immunotherapy combined with chemotherapy could also increase the effectiveness. Research ofpancreatic cancer vaccine has made some progress. The immunity enhancing function of some traditional herbshave been reported, such as Ginsenoside Rg3, which could enhance T-cell subsets and NK cell activity inpancreatic cancer patients with chemotherapy.
胰腺癌是恶性程度最高的肿瘤,并且对常规治疗无效.近年来,更多研究关注于基因工程修饰T细胞、T细胞检测点抑制剂、树突状细胞和细胞因子诱导的杀伤细胞对胰腺癌的治疗作用;胰腺原位和瘤外肿瘤冷冻免疫治疗,免疫治疗联合化疗也可增强抗肿瘤的作用;胰腺癌疫苗研究也取得一定进展.现代药理学研究也发现中草药的免疫增效作用,比如人参皂苷Rg3能够增强胰腺癌化疗病人T细胞亚群和NK细胞活性.
基金
This study was supported by National Natural Science Foundation of China （81341068）.
