摘要
过度炎症反应严重危害人类身体健康,目前的抗炎药物大多存在多种副作用,寻找新的抗炎药物是治疗炎症反应的一种有效途径。本文以没食子酸甲酯为先导化合物,合成了一系列没食子酸甲酯结构类似物,所有化合物均经过核磁共振氢谱、碳谱和质谱和分析进行结构确认,并初步进行了体外抑制脂多糖(LPS)诱导的炎症因子释放的抗炎活性测试。
Excessive inflammation can lead to severely harm human health, Most of the current anti-inflammatory drugs have a lot of side effects, and discovery of new lead compound of anti-inflammation is an effective way to control the disease. In this paper, we chose methyl gallate as the lead compound, synthesized a series of methyl gallate derivatives. The structures were confirmed by 1H NMR, 13C NMR and MS, and the inhibition of LPS induced cytokines releases was preliminary studied in vitro.
作者
陈慧珍
邱胤达
陈英英
舒升
陈显鑫
李校堃
Chen HuizhenL, Qiu Yinda2, Chen Yingying1, Shu Sheng3, Chen Xianxin3, Li Xiaokun1,2(1. College of Chemistry ＆ Materials Engineering, Wenzhou University, Wenzhou 325035; 2. College of Life and Environmental Science Wenzhou University, Wenzhou 325035; 3. College of Pharmacy, Wenzhou Medical University, Wenzhou 325035, Chin)
出处
《广东化工》
CAS
2018年第14期17-18,31,共3页
Guangdong Chemical Industry
基金
国家自然科学基金项目(81773579)
关键词
没食子酸甲酯
抗炎
活性
methyl gallate
anti-inflammation
activity
