摘要
背景:近年来,控释靶向纳米粒子在恶性肿瘤化疗方面得到越来越广泛的应用。目的:综述控释靶向纳米粒子在骨肿瘤治疗方面的应用及其发展前景。方法:以"Nanoparticles,controlled drug release,bone tumor or osteosarcoma or Ewing sarcoma"为关键词,检索Pub Med、Web of Science、NCBI数据库中近十年来关于纳米控释靶向粒子在骨肿瘤治疗方面应用的最新进展。结果与结论:骨肿瘤是一种具有较高发病率和死亡率的恶性肿瘤,严重威胁人类的健康。与传统化疗药物相比,纳米粒子具有控制释放,联合、协同治疗,跨越生物屏障,靶向治疗,增强肿瘤积累,延长循环时间等优势。控释靶向纳米粒子能针对骨肿瘤复杂的微环境实现靶向、精密调控,从而解决传统化疗所具有的不良反应和耐药性等问题。如何在保证载药率的同时提高纳米药物在肿瘤部位渗透效率、减少系统毒性、实现纳米药物治疗的多功能性是最终的研究目标。相信控释靶向纳米粒子以其固有的优势配合其智能、协同的载药方式,必将在这一交叉学科发挥更大的作用。
BACKGROUND： In recent years, controlled-release nanoparticles have become popular in the treatment of malignant tumors. OBJECTIVE： To summarize the applications and prospects of controlled-release nanoparticles in the treatment of bone tumors METHODS： By using “nanoparticles, controlled drug release, bone tumor or osteosarcoma or Ewing sarcoma” as keywords, we retrieved PubMed, Web of Science and NCBI for the articles published in the past 10 years about the research progress of controlled-release nanoparticles in the treatment of bone tumors.RESULTS AND CONCLUSION： Bone tumor is a malignant tumor with high morbidity and mortality, and seriously threatens the quality of life of human beings. Compared with traditional chemotherapeutic drugs, nanoparticles have the advantages of controlled release, synergistic treatment, crossing the biological barrier, targeted therapy, enhancing tumor accumulation and prolonging the circulation time. Controlled-release nanoparticles can target the complex microenvironment of bone tumors and enable targeting and precision control, which can minimize side effects and drug resistance of traditional chemotherapy. Our ultimate goal of research on controlled-release nanoparticles is to increase the penetration rate of nano-drugs at the tumor site and reduce the systemic toxicity while ensuring drug-loading rate, and to achieve the versatility of nano-drug treatments. We believe that the controlled-release nanoparticles with inherent advantages combined with intelligent and collaborative drug deliveries will play a considerable role in this interdisciplinary field.
作者
马鸿云
庄新明
考彦斌
汪振宇
曲志刚
宋清旭
许维国
刘一
Ma Hong-yun;Zhuang Xin-ming;Kao Yan-bin;Wang Zhen-yu;Qu Zhi-gang;Song Qing-xu;Xu Wei-guo;Liu Yi(Department of Spine,First Hospital of Jilin University,Changchun 130021,Jilin Province,China;Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,Jilin Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2018年第26期4247-4252,共6页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金青年科学基金项目(51603204)~~
