摘要
肝功能障碍相关凝血病的机制主要为大多数凝血因子和抗凝蛋白C、S合成减少,血小板计数下降,凝血因子Ⅷ和血管性假性血友病因子合成增加,组织纤溶酶原激活物水平上调,凝血状态可以呈现正常、高凝或低凝.应用全血监测设备监测肝功能障碍患者,可以准确判断凝血状态,指导精准的替代治疗或抗凝治疗.
Liver dysfunction-associated coagulopathy may manifest as hypercoagulation, hypocoagulation or normal coagulation, resulting in reduced synthesis of most coagulation factors, protein C and protein S, drop of platelet count, and increase of coagulation factor Ⅷ, Von Willebrand factor and tissue plasminogen activator. The use of viscoelastic coagulation monitoring equipment can accurately determine the coagulation state of patients with liver failure and guide accurate replacement therapy or anticoagulant therapy.
作者
宋景春
Jing-Chun Song(Department of Intensive Medicine,The 94^th Hospital of The Chinese People＇s Liberation Army,Nanchang 330002,Jiangxi Province,Chin)
出处
《世界华人消化杂志》
CAS
2018年第19期1156-1160,共5页
World Chinese Journal of Digestology
基金
国家自然科学基金面上项目
No.81573783
江西省卫健委科技计划
No.20185556~~
关键词
肝功能障碍
凝血
血栓弹力图
监测
Liver dysfunction
Coagulation
Thromboe-lastography
Monitoring
