摘要
目的:探讨外周血淋巴细胞亚群与初诊急性髓系白血病(AML,非M3)患者预后的关系。方法:纳入66例初诊AML患者,采用DCAG方案诱导治疗。回顾性分析患者淋巴细胞亚群及临床资料,并分析其与预后的关系。结果:在AML 4种亚型中,淋巴细胞亚群的比例未发现有显著差异。NK细胞比例在达完全缓解(CR)患者中显著高于未达CR的患者(19.05%∶13.63%,P<0.05)。白细胞计数、CD3+T细胞绝对计数、CD4+T细胞绝对计数、年龄、初次诱导达CR及FLT3-ITD突变是影响预后的危险因素(P<0.05);多因素分析显示,白细胞计数、CD4+/CD8+比值及初次诱导是否达CR是影响预后的独立危险因素(P<0.05)。结论:淋巴细胞亚群分析对AML患者预后评估有较重要意义。
Objective：To investigate the relationship between peripheral blood lymphocyte subsets and prognosis in elderly patients with acute myeloid leukemia（AML,non-M3）.Method：A total of 66 patients who were newly diagnosed AML and treated with DCAG therapy were included.The relationship between lymphocyte subsets and clinical data and prognosis was analyzed retrospectively.Result：In the 4 types of AML,there was no significant difference in the proportion of lymphocyte subsets.The proportion of NK cells in complete remission（CR）patients was significantly higher than that in patients without CR（19.05% vs 13.63%,P〈0.05）.The absolute count of white blood cell,CD3＋T cells,CD4＋T cells,age,achievement of CR after first induction and FLT3-ITD mutation were the factors affecting the prognosis,whereas the absolute count of white blood cell,CD4＋/CD8＋ratio and achievement of CR after first induction were independent risk factors（P〈0.05）.Conclusion：Lymphocyte subsets analysis is important for the prognosis of AML patients.
作者
李珊
杨丽葭
赵慧慧
洪鸣
朱雨
李建勇
钱思轩
LI Shan;YANG Lijia;ZHAO Huihui;HONG Ming;ZHU Yu;LI Jianyong;QIAN Sixuan(Department of Hematology,the First Affiliated Hospital of Nanjing Medical University,Jiangsu Province Hospital,Key Laboratory of Hematology of Nanjing Medical University,Nanjing,210029,China)
出处
《临床血液学杂志》
CAS
2018年第4期523-527,共5页
Journal of Clinical Hematology
基金
国家自然科学基金资助项目(No:81570134)
