摘要
目的探讨缬沙坦联合氨氯地平治疗老年高血压疗效及安全性。方法选取2016年12月至2017年11月我院诊治老年高血压患者96例随机分为联合组(缬沙坦联合氨氯地平治疗,48例)和对照组(氨氯地平治疗,48例),比较两组患者治疗前后血压水平、疗效及药物不良反应发生率。结果治疗前,两组患者在SBP、DBP水平方面比较无显著统计学差异(P>0.05);治疗后3月两组患者SBP、DBP水平与治疗前比较均显著下降,但联合组患者下降程度显著于对照组(P<0.05)。联合组患者疗效显著于对照组,(P<0.05)。两组患者水肿、咳嗽、头晕、乏力、胃肠不适、皮疹发生率比较无统计学意义(P>0.05)。结论影响AECOPD合并深静脉血栓形成危险因素较多,临床中应根据相关危险因素针对性预防和干预,以降低AECOPD患者深静脉血栓发生风险。
Objective To investigate the efficacy and safety of valsartan combined with amlodipine in the treatment of senile hy- pertension. Methods 96 case of elderly hypertensive patients in our hospital during Dec. ,2016 - Nov. ,2017 were selected as stud- ying object, the patients were randomly divided into combined group （valsartan combined with amlodipine treatment, 48 cases ） and control group （amlodipine treatment, 48 cases）. The blood pressure, curative effect and incidence of adverse drug reactions were com- pared between the two groups before and after treatment. Results Before treatment, there was no significant difference in SBP and DBP between the two groups （P 〉 0.05）. The levels of SBP and DBP in both groups after 3 months of treatment were significantly de- creased compared with those before treatment, and there was a significant decrease in the combination group than that in the control group （ P 〈 0.05）. The efficacy of the combination group was significantly higher than that of the control group [ 97.92% vs 83.33%, P 〈 0. 05 ]. The incidence of edema, cough, dizziness, fatigue, gastrointestinal discomfort and rash in the two groups were not statisti- cally significant （P 〉 0.05）. Conclusion Valsartan combined with amlodipine in the treatment of senile hypertension has a signifi- cant effect and high medication safety.
作者
王锋垲
陈奕权
陈燕妆
刘旸
WANG Feng-kai(General medicine,Chaozhou central hospital,Chaozhou 521000,China)
出处
《牡丹江医学院学报》
2018年第4期25-27,共3页
Journal of Mudanjiang Medical University
