摘要
目的探讨非小细胞肺癌骨转移患者的各临床病理特征对无骨相关事件生存期与生存期的影响。方法选取哈尔滨医科大学附属肿瘤医院2007年1月至2012年1月间211例非小细胞肺癌骨转移患者,对其临床病例资料进行单因素与多因素分析,再将是否双磷酸盐治疗这一因素按首诊临床分期进行分层处理。结果首诊时临床分期、是否有骨相关事件是影响生存期的独立风险因素(P <0. 05),首诊时临床分期、是否有骨痛、原发灶是否放疗、是否化疗是影响无骨相关事件生存期的独立风险因素(P <0. 05)。Ⅰ、Ⅱ、Ⅲ期的患者双磷酸盐治疗组的无骨相关事件生存期明显长于无双磷酸盐治疗组,而Ⅳ期的患者双磷酸盐治疗组与无双磷酸盐治疗组的无骨相关事件生存期无明显差别。结论明确非小细胞肺癌骨转移患者无骨相关事件生存期与生存期的影响因素有助于提高其生活质量,并延长生存期。
Objective To investigate the impact of the clinical and pathological prognostic fac- tors on SRE-free survival and overall survival in non-small cell lung cancer patients with bone metastases. Methods Two hundred and eleven-one non-small cell lung cancer patients with bone metastases treated in the Affiliated Cancer Hospital of Harbin Medical University between January 2003 and January 2010 were selected for univariate and multivariate analysis based on their clinical data, and bisphosphonate therapy was evaluated based on the first diagnosis of clinical stage. Results Clinical stage of the first diagnosed, with or without SRE were inde- pendent factors affecting the prognosis of overall survival （ P 〈 0.05 ） , clinical stage of the first diagnosed, with or without pain, with or without primary tumor radiotherapy, and with or with- out chemotherapy were independent factors affecting the prognosis of SRE-free survival （P 〈 0.05 ）. Survival period of I / II /III stage group with bisphosphonate therapy was significantly longer than the without bisphosphonate therapy group, and there was no significant difference in IV stage patients between with bisphosphonates treated and no bisphosphate treated in SRE-free survival. Conelusion Clearing the influence factors on SRE-free survival and overall survival in non-small cell lung cancer patients with bone metastases can improve their quality of life and prolong overall survival.
作者
刘东辉
王旭瑶
吴瑾
LIU Dong-hui;WANG Xu-yao;WU Jin(Department of Internal Medicine,The Affiliated Cancer Hospital of Harbin Medical Universi-ty,Harbin 150081,China;Hematologic oncology Department,Second Hospital of Harbin,Harbin 150056,China;Department of Pharmacology,Harbin Medical University,Harbin 150081,China)
出处
《哈尔滨医科大学学报》
CAS
2018年第2期136-141,共6页
Journal of Harbin Medical University
关键词
非小细胞肺癌
骨转移
无骨相关事件生存期
生存期
单因素分析
多因素分析
non small cell lung cancer
bone metastases
SRE-free survival
overall survival
univariate analysis
multivariate analysis
