摘要
目的:观察津力达颗粒联合硫辛酸对2型糖尿病性周围神经病变(diabetic peripheral neuropathy,D P N)的临床疗效。方法:选取2016年8月至2017年10月于吉林大学第二医院内分泌科就诊的2型糖尿病合并周围神经病变患者62例。随机分为观察组和对照组,每组各31例。对照组在院期间给予硫辛酸注射剂0.6 g/d静脉点滴,出院后改为硫辛酸胶囊0.2 g口服,3次/d;观察组在对照组基础上加用津力达颗粒9 g口服,3次/d,两组连续治疗12周。比较两组患者治疗前后的临床疗效、多伦多临床评分系统(Toronto clinical scoring system,TCSS)评分、神经传导速度[胫神经及腓总神经的运动传导速度(motor nerve conduction velocity,MNCV)和感觉传导速度(sensory nerve conduction velocity,SNCV)]、空腹血糖(fasting blood glucose,FPG)、餐后2 h血糖(2 h PG)及糖化血红蛋白(Hb A1c)。结果:经过12周的治疗,观察组的有效率显著高于对照组(P<0.05);两组患者的TCSS评分降低、神经传导速度增加(P<0.05),且观察组较对照组差异更显著,具有统计学意义(P<0.05);治疗后观察组FPG、餐后2 h PG及Hb A1c水平均较对照组有所下降,但差异无统计学意义(P>0.05)。结论:津力达颗粒联合硫辛酸治疗2型DPN,既可改善患者临床症状,又可加快神经传导速度,疗效显著。
Objective： To observe the clinical effect of Jinlida granules combined with alpha-lipoic acid on type 2 diabetic peripheral neuropathy（DPN）. Methods： A total of 62 type 2 diabetic patients with DPN from August 2016 to October 2017 in Second Hospital of Jilin University were randomly divided into a treatment group and a control group, with 31 in each group. The control group received alpha-lipoic acid 0.6 g/d in normal saline 250 m L given by intravenous once a day during the hospital, and then changed to alpha-lipoic acid capsule（0.2 g/time, 3 times/d） after discharge. The treatment group was added Jinlida granules（9 g/time, 3 times/d） on the basis of the control group. The treatment lasted for 12 weeks. The changes of symptoms and signs, Toronto clinical scoring system（TCSS） score, nerve conduction velocity, fasting blood glucose（FPG）, 2 h PG and Hb A1 c were measured and compared. Results： After 12 weeks of treatment, the effective rate in the treatment group was significantly higher than that in the control group（P〈0.05）. Compared with before treatment, the TCSS score was decreased and the nerve conduction velocity was accelerated significantly after 12 weeks of treatment in both groups（all P〈0.05）, and the difference of the treatment group was more obvious, with statistical significance（P〈0.05）. After treatment, FPG, 2 h PG and Hb A1 c in the treatment group tended to decrease compared with the control group, but the difference was not statistically significant（P〉0.05）. Conclusion： Jinlida granules combined with alpha-lipoic acid in the treatment of type 2 DPN not only can improve the clinical symptoms but also accelerate the nerve conduction velocity, and the curative effect is definite.
作者
曹桂
彭静静
赵淑杰
CAO Gui;PENG Jingjing;ZHAO Shujie(Department of Endocrinology,Second Hospital of Jilin University,Changchun 130021,China)
出处
《临床与病理杂志》
2018年第6期1234-1238,共5页
Journal of Clinical and Pathological Research
