摘要
目的分析某院重症监护病房(ICU)中的常见病原菌情况及特殊使用级抗菌药物的使用情况,为促进特殊使用级抗菌药物合理用药提供参考。方法收集2015年10月至2017年9月某院ICU患者的住院病历,统计分析病原菌的分布情况和特殊使用级抗菌药物的使用频度(DDDs)、抗菌药物使用强度(AUD)。结果 ICU送检样本共检出644株菌株,鲍曼不动杆菌所占比例最高(28.42%),其次为铜绿假单胞菌(12.27%)。多重耐药菌(MDRO)分离率为47.45%(473株/644株),以耐碳青霉烯类鲍曼不动杆菌(CRAB)、产超广谱β-内酰胺酶(ESBLs)大肠埃希菌、产超广谱β-内酰胺酶(ESBLs)肺炎克雷伯菌、耐碳青霉烯类铜绿假单胞菌(CRPA)、耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)为主。结论某院特殊使用级抗菌药物的临床应用较合理,但仍需加强监管,减少耐药菌产生。
Objective To analyze the common pathogens and utilization of antibiotics for special use in intensive care unit（ ICU） in the hospital,and provide reference for rational use of antibiotics. Methods All medical records of ICU patients from October 2015 to September 2017 were collected. We analyzed the distribution of pathogens,the definied daily dose（ DDDs） and antibiotics use density（ AUD） of antibiotics for special use. Results A total of 644 strains were detected in samples of ICU,the highest proportion of Acinetobacter baumannii（ 28. 42%）,followed by Pseudomonas aeruginosa（ 12. 27%）. These paration rate of multiple drug resistant organism（ MDRO） is 47. 45%（ 473 cases/644 cases）, mainly with carbapenem-resistant Acinetobacter baumannii（ CRAB）,extended spectrum β lactamases（ ESBLs） producing Escherichia coli,ESBLs producing Klebsiella pneumoniae,carbapenem-resistant Pseudomonas aeruginosa（ CRPA）,methicillin resistant coagulase negative Staphylococcus（ MRCNS）. Conclusion The application of antibiotics for special use is reasonable in the hospital,but we still need to strengthen supervision and reduce the production of resistant bacteria.
作者
郑晨
何晓静
菅凌燕
ZHENG ChenI HE Xiao -jing2 JIAN Ling - yan1,2(1. School of Life Science and Biopharmaceuticals , Shenyang Pharmaceutical University, Shenyang 110016, China; 2 Department of Pharmacy, Shengjing Hospital of China Medical University, Shenyang 110004, Chin)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2018年第14期1700-1702,共3页
The Chinese Journal of Clinical Pharmacology
关键词
特殊使用级抗菌药物
病原菌
使用强度
耐药性
合理用药
antibiotics for special use
pathogens
antimicrobial use intensity
bacterial resistance
rational drug
