摘要
目的莱斯顿型埃博拉病毒(Reston Ebola virus,REBOV)是目前唯一对人不致病的丝状病毒,对其他哺乳动物多为无症状感染,其致病机制尚未完全明确。系统发育分析揭示REBOV基因组进化速率和氨基酸替代速率最快,未来存在人致病突变的可能。了解和掌握REBOV的生物学特征,探讨其可能的传播方式对今后的防控有着重要的意义。
OBJECTIVE As a member of filoviridae family,Reston Ebola virus（REBOV）is nonpathogenic in humans,and it can be asymptomatically infected in other mammals.The reasons for this discrepancy remain unclear.Phylogenetic analysis revealed that REBOV genomes evolved most rapidly and had the highest rate of amino acid substitutions,which could make the mutation of pathogenicity to humans possible.It is of great significance to understand the biological characteristics of REBOV and explore the transmission routes so as to facilitate the control and prevention.
作者
史庆丰
高晓东
陈翔
米宏霏
王伊伦
胡必杰
SHI Qing-feng;Gao Xiao-dong;CHEN Xiang;MI Hong-fei;WANG Yi-lun;HU Bi-jie(Zhongshan Hospital,Fudan University,Shanghai 200032,Chin)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2018年第13期2072-2074,2080,共4页
Chinese Journal of Nosocomiology
关键词
莱斯顿型埃博拉
致病性
传播
进化
Reston Ebola virus
Pathogenicity
Transmission
Evolution
